Document Detail


Cellular localization of epidermal-type and brain-type fatty acid-binding proteins in adult hippocampus and their response to cerebral ischemia.
MedLine Citation:
PMID:  19623607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study aimed at an analysis of expression of epidermal-type and brain-type fatty acid-binding proteins (E-FABP and B-FABP, also called FABP5 and FABP7, respectively) in adult hippocampus and their potential value as neuroprotective factors after ischemic brain damage in monkey model. The immunostaining and Western blotting results show that FABP5 was mainly expressed in neurons, whereas FABP7 was primarily expressed in astrocytes and progenitors of the subgranular zone (SGZ). Interestingly, FABP5 expression in neurons increased in cornu Ammonis 1 (CA1) and remains stable within dentate gyrus (DG) after ischemia; FABP7 expression increased within both CA1 and SGZ. This indicates a potential role for FABP5 and FABP7 in intracellular fatty acid transport within different neural cells. The change in FABP5-7 expression within CA1 and DG of the adult postischemic hippocampus was compatible with previous findings of downregulation in CA1 neurons and upregulation in SGZ progenitor cells after ischemia. Altogether, the present data suggest that polyunsaturated fatty acids, such as docosahexaenoic acid, may act via FABP5 or 7 to regulate adult postischemic hippocampal neuronal antiapoptosis or neurogenesis in primates.
Authors:
Dexuan Ma; Minmin Zhang; Yoshimi Mori; Chengjun Yao; Christian P Larsen; Tetsumori Yamashima; Liangfu Zhou
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hippocampus     Volume:  20     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-01     Completed Date:  2010-09-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  811-9     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Wiley-Liss, Inc.
Affiliation:
Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Astrocytes / metabolism
Blotting, Western
Brain Ischemia / metabolism*
Fatty Acid-Binding Proteins / biosynthesis*
Gene Expression
Gene Expression Profiling
Hippocampus / metabolism*
Image Processing, Computer-Assisted
Immunohistochemistry
Macaca
Neurons / metabolism*
Stem Cells / metabolism
Chemical
Reg. No./Substance:
0/Fatty Acid-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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