Document Detail


Cellular localisation of metabotropic glutamate receptors in the mammalian optic nerve: a mechanism for axon-glia communication.
MedLine Citation:
PMID:  9001707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It has been proposed that neurotransmitter signalling can occur between axons and glia in the mammalian optic nerve in the absence of synaptic specialisations, and that this may be glutamate mediated. Here, the cellular distribution of five metabotropic glutamate receptors (mGluR's 1a, 1b, 1c, 2/3 and 5) have been assessed in the rat optic pathway using specific antibodies. Positive immunoreactivity is found for mGluR2/3 and 5. Both are found in axons, although only mGluR5 is present in the majority of these. Strong immunoreactivity for mGluR2/3 is found in cells in the optic pathway and thalamus. The cellular morphology and distribution is consistent with their being astrocytes. Examination of brain sections stained for mGluR2/3 is consistent with this notion, with many cells having end-feet processes terminating on blood vessels or the pial surface. The axonal immunoreactivity could represent the presence of these receptors on axons, but it is more probable that the receptor protein synthesised in the ganglion cell soma is being transported to the cell terminal in sufficient concentration to be revealed by immunohistochemistry. The reason for the axon-astrocyte signalling is unclear, and may be associated with metabolic coupling. In development, communication between axons and glia mediates a range of functions including pathway selection and myelination. It is probable that in the adult this form of signalling underpins a range of functions that have yet to be described.
Authors:
G Jeffery; C Sharp; B Malitschek; T E Salt; R Kuhn; T Knöpfel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research     Volume:  741     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-04-02     Completed Date:  1997-04-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  75-81     Citation Subset:  IM    
Affiliation:
Institute of Ophthalmology, University College London, UK. g.jeffery@ucl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibody Specificity
Axons / physiology*
Blotting, Western
Cell Communication / physiology*
Cell Line
Humans
Immunohistochemistry
Male
Neuroglia / physiology*
Optic Chiasm / cytology,  physiology
Optic Nerve / cytology*,  physiology*
Rats
Receptors, Metabotropic Glutamate / physiology*
Visual Pathways / cytology,  physiology
Chemical
Reg. No./Substance:
0/Receptors, Metabotropic Glutamate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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