Document Detail


Cellular impedance biosensors for drug screening and toxin detection.
MedLine Citation:
PMID:  17710258     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cell-based impedance biosensing is an emerging technology that can be used to non-invasively and instantaneously detect and analyze cell responses to chemical and biological agents. This article highlights the fabrication and measurement technologies of cell impedance sensors, and their application in toxin detection and anti-cancer drug screening. We start with an introduction that describes the capability and advantages of cell-based sensors over conventional sensing technology, followed by a discussion of the influence of cell adhesion, spreading and viability during cell patterning on the subsequent impedance measurements and sensing applications. We then present an electronic circuit that models the cell-electrode system, by which the cellular changes can be detected in terms of impedance changes of the circuit. Finally, we discuss the current status on using cell impedance sensors for toxin detection and anti-cancer drug screening.
Authors:
Fareid Asphahani; Miqin Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2007-06-26
Journal Detail:
Title:  The Analyst     Volume:  132     ISSN:  0003-2654     ISO Abbreviation:  Analyst     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-21     Completed Date:  2007-12-27     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  England    
Other Details:
Languages:  eng     Pagination:  835-41     Citation Subset:  IM    
Affiliation:
Department of Materials Science & Engineering, 302L Roberts Hall, University of Washington, Seattle, Washington 98195-2120, USA.
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MeSH Terms
Descriptor/Qualifier:
Antineoplastic Agents / analysis*
Biosensing Techniques*
Cell Physiological Phenomena*
Cytotoxins / analysis*
Drug Evaluation, Preclinical / instrumentation,  methods*
Electric Impedance
Electrochemistry / instrumentation,  methods
Humans
Microarray Analysis / instrumentation,  methods
Microelectrodes
Grant Support
ID/Acronym/Agency:
R01 GM075095-01A1/GM/NIGMS NIH HHS; R01 GM075095-02/GM/NIGMS NIH HHS; R01GM075095/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Cytotoxins
Comments/Corrections

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