Document Detail


Cellular immunophenotypes in human embryonic, fetal and adult heart.
MedLine Citation:
PMID:  22732799     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The cellular immunoprofile of cardiac dysfunctions and lesions of ischemic etiology are insufficiently studied to date, especially regarding the contribution of non-cardiomyocytic structures. Aiming to explore this immunoprofile, we used immunohistochemistry applied on embryonic, fetal and adult normal or ischemic myocardium. We observed a decrease of smooth muscle alpha-actin expression in fetal vs. embryonic cardiomyocytes, its absence in normal adult myocardium and its intense expression in the fibrotic scars of ischemic myocardium. DDR2 and vimentin, which are present in the interstitial cells and cardiomyocytes of the embryo, fetus and normal adult heart, are absent in the fibrotic scar tissue and cicatricial infarction, the latter expressing smooth muscle alpha-actin and CD34. This suggested that myofibroblasts and not local fibroblasts that participate in ischemic remodeling. An EGFR-positive vascular network was better represented in the ischemic heart than in the adult normal one, a fact possibly related to EGFR implication in cardiac ischemic pre- and post-conditioning. Therefore, cardiomyocytes and non-cardiomyocytic cells have an undulating immunoprofile according to the intrauterine life stage or age after birth, and a variable contribution in cardiac lesions, mostly in ischemic ones.
Authors:
Alina Grigore; D Arsene; Fl Filipoiu; Florina Cionca; Simona Enache; M Ceauşu; Maria Comănescu; Florica Stăniceanu; Carmen Ardeleanu
Related Documents :
19955769 - Ischemia-modified albumin reduction after coronary bypass surgery is associated with th...
16319049 - Mild hypothermia impairs left ventricular diastolic but not systolic function.
7671379 - Normothermic continuous antegrade blood cardioplegia does not prevent myocardial edema ...
2106749 - Ultrastructural effects induced by global ischaemia on the av node compared with the wo...
21606749 - Contribution of fetal tricuspid regurgitation in first-trimester screening for major ca...
14690739 - Maintenance of physiological coronary endothelial function after 3.3 h of hypothermic o...
1354569 - Contemporary medical management of left ventricular dysfunction and congestive heart fa...
21232279 - Retroviral vectors to study cardiovascular development.
20922539 - Predictive value of the relative lymphocyte count in coronary heart disease.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie     Volume:  53     ISSN:  1220-0522     ISO Abbreviation:  Rom J Morphol Embryol     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112454     Medline TA:  Rom J Morphol Embryol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  299-311     Citation Subset:  IM    
Affiliation:
Department of Pathology, "Victor Babes" National Institute of Pathology, Bucharest, Romania; cmardeleanu@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Chronic gastritis with intestinal metaplasia: clinico-statistical, histological and immunohistochemi...
Next Document:  Acinic cell carcinoma of the salivary glands: a retrospective clinicopathologic study of 12 cases.