Document Detail

Cellular immunity to possible synovial antigens in rheumatoid arthritis.
MedLine Citation:
PMID:  7458429     Owner:  NLM     Status:  MEDLINE    
A reaction has been demonstrated between extracts of synovial cells removed from intact rheumatoid knee joints and autologous leucocytes. The cell mediated immunity test system used was leucocyte migration inhibition. Variable reactions were found with a spectrum of allogeneic extracts when donor leucocytes came from married or transfused females or transfused males. Leucocytes from healthy (nontransfused) males showed no reaction with any of the extracts. As a period of cell culture was used prior to preparation of this extract to remove nonspecific inhibitory substances, native immunoglobulins, and complexes, the data are best explained by the presence of a foreign pathogen or altered cell component in the synovial cells of these rheumatoid patients.
A D Robinson; K D Muirden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  39     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-24     Completed Date:  1981-03-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
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MeSH Terms
Antigens / immunology*
Arthritis, Rheumatoid / immunology*
Cell Migration Inhibition
Immunity, Cellular*
Knee Joint / immunology*
Leukocytes / immunology
Middle Aged
Synovial Membrane / immunology*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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