| Cellular immunity to possible synovial antigens in rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 7458429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A reaction has been demonstrated between extracts of synovial cells removed from intact rheumatoid knee joints and autologous leucocytes. The cell mediated immunity test system used was leucocyte migration inhibition. Variable reactions were found with a spectrum of allogeneic extracts when donor leucocytes came from married or transfused females or transfused males. Leucocytes from healthy (nontransfused) males showed no reaction with any of the extracts. As a period of cell culture was used prior to preparation of this extract to remove nonspecific inhibitory substances, native immunoglobulins, and complexes, the data are best explained by the presence of a foreign pathogen or altered cell component in the synovial cells of these rheumatoid patients. |
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Authors:
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A D Robinson; K D Muirden |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 39 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1980 Dec |
Date Detail:
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Created Date: 1981-03-24 Completed Date: 1981-03-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 539-44 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antigens / immunology* Arthritis, Rheumatoid / immunology* Cell Migration Inhibition Female Humans Immunity, Cellular* Knee Joint / immunology* Leukocytes / immunology Male Middle Aged Synovial Membrane / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Antigens |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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