Document Detail

Cellular immune reactivity in patients with rheumatoid arthritis and effects of levamisole.
MedLine Citation:
PMID:  604477     Owner:  NLM     Status:  MEDLINE    
Cellular immune reactivity was examined in control subjects and in 16 patients with rheumatoid arthritis before and after administration of levamisole. Prior to levamisole treatment, this population of patients with rheumatoid arthritis had diminished cellular immunity as measured by skin test reactivity, lymphocyte stimulation by antigen and by PHA, lymphocyte count and percentage and absolute numbers of long-incubation rosette-forming cells (RFC). Administration of levamisole caused enhancement of skin test reactivity and flares at dinitrochlorobenzene (DNCB) test sites which were not paralleled by an increase in lymphocyte stimulation by the same antigens in vitro or enhancement in the PHA response. The increase in lymphocyte count and RFC was borderline (p = .06). Of the 16 patients who received levamisole for three months, nine patients showed at least one physical sign of improvement, five patients remained unchanged, and two patients experienced progression of their disease.
C M Basch; L E Spitler; E G Engleman; E P Engleman
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of rheumatology     Volume:  4     ISSN:  0315-162X     ISO Abbreviation:  J. Rheumatol.     Publication Date:  1977  
Date Detail:
Created Date:  1978-04-17     Completed Date:  1978-04-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7501984     Medline TA:  J Rheumatol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  377-88     Citation Subset:  IM    
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MeSH Terms
Arthritis, Rheumatoid / drug therapy,  immunology*
Blood Sedimentation
Immunity, Cellular / drug effects*
Leukocyte Count
Levamisole / pharmacology*,  therapeutic use
Lymphocytes / immunology
Middle Aged
Rosette Formation
Skin Tests
Reg. No./Substance:

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