| Cellular immune reactions in the lung. | |
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MedLine Citation:
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PMID: 23278750 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The lung constantly interacts with the environment through thousands of liters of air that are inhaled daily. This continually transports toxic chemicals and particles or pathogenic microorganisms deep into the respiratory system, posing a challenge to physicochemical barriers and the local immune system. Thus, complex structures and mechanisms have evolved to recognize and fend off environmental dangers while at the same time allowing efficient gas exchange. Here we review our current knowledge regarding cellular mechanisms of the immune system in context with the highly specialized anatomical features of the airways and especially the alveolar compartment. The focus is on fungal and viral infections, merging anatomical aspects well known to pulmonologists with fundamental immunological concepts. We discuss the specialized morphological constraints of immune cells compressed under a continuous layer of the surfactant lining within alveoli as well as the importance of functional polarization of respiratory tract epithelia. Furthermore, we summarize the different types of innate and adaptive immune cells and their relative contribution to lung homeostasis with respect to localization. Finally, we provide a list of currently unresolved questions with high relevance for the field that might serve as food for thought regarding future research directions. |
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Authors:
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Mike Hasenberg; Sabine Stegemann-Koniszewski; Matthias Gunzer |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Immunological reviews Volume: 251 ISSN: 1600-065X ISO Abbreviation: Immunol. Rev. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-01-02 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7702118 Medline TA: Immunol Rev Country: England |
Other Details:
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Languages: eng Pagination: 189-214 Citation Subset: IM |
Copyright Information:
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© 2012 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd. |
Affiliation:
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Institute of Experimental Immunology and Imaging, University of Duisburg/Essen, University Hospital, Essen, Germany. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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