| Cellular immune findings in Lyme disease. Correlation with serum IgM and disease activity. | |
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MedLine Citation:
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PMID: 6237576 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cellular immune findings were studied in 48 patients with various stages of Lyme disease. At each stage, some patients, particularly those with neuritis or carditis, had elevated serum IgM levels and lymphopenia. During early disease, mononuclear cells tended to respond normally to phytohemagglutinin, and spontaneous suppressor cell activity was greater than normal. Later, during active neuritis, carditis, or arthritis, the trend was toward heightened phytohemagglutinin responsiveness and less suppression than normal. By multiple regression analysis, serum IgM levels correlated directly with disease activity (p = 0.025) and inversely with the number of T cells (p = 0.02); during acute disease only, elevated IgM levels correlated with increased phytohemagglutinin responsiveness (p = 0.004) and decreased suppressor cell activity (p = 0.03). Decreased suppression, observed later in the disease, may permit damage to host tissues because of either autoimmune phenomena or a heightened response to the Lyme spirochete. |
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Authors:
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C M Moffat; L H Sigal; A C Steere; D H Freeman; J M Dwyer |
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Publication Detail:
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Type: Case Reports; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of medicine Volume: 77 ISSN: 0002-9343 ISO Abbreviation: Am. J. Med. Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1984-11-09 Completed Date: 1984-11-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0267200 Medline TA: Am J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 625-32 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Cells, Cultured Child Convalescence Female Humans Immunity, Cellular Immunoglobulin M / analysis* Leukocyte Count Lyme Disease / immunology*, pathology Male Middle Aged Phytohemagglutinins / pharmacology Prognosis Regression Analysis T-Lymphocytes / drug effects T-Lymphocytes, Regulatory / immunology |
| Grant Support | |
ID/Acronym/Agency:
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AI-07174/AI/NIAID NIH HHS; AM-07107/AM/NIADDK NIH HHS; AM-20358/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin M; 0/Phytohemagglutinins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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