Document Detail

Cellular hypertrophy in subcutaneous small arteries of patients with renovascular hypertension.
MedLine Citation:
PMID:  10775564     Owner:  NLM     Status:  MEDLINE    
Structural alterations of small arteries in patients with essential hypertension are characterized by inward eutrophic remodeling. However, small arteries in patients with secondary hypertension, as well as in experimental models of hypertension with high circulating renin, are characterized by inward hypertrophic remodeling, which is characterized by smooth muscle cell hypertrophy in animal models. The aim of our study was to determine whether remodeling of subcutaneous small arteries in patients with secondary forms of hypertension is associated with smooth muscle cell hypertrophy and/or alterations in the elastic modulus of the vessel wall. Fifteen patients with renovascular hypertension, 9 with primary aldosteronism, and 13 with essential hypertension and 9 normotensive subjects were included in the study. A biopsy of subcutaneous fat was taken from all subjects. Small arteries were dissected, and morphology was determined on a micromyograph. Unbiased estimates of cell volume and number were made in fixed material. From the resting tension-internal circumference relation of the small arteries, the incremental elastic modulus was calculated and plotted as a function of wall stress. Blood pressure was greater in patients with essential hypertension, renovascular hypertension, or primary aldosteronism than in normotensive subjects, but no significant difference was observed among the 3 groups of hypertensive patients. The media/lumen ratio, the medial cross-sectional area, and the smooth muscle cell volume were significantly greater in patients with renovascular hypertension than in normotensive subjects and patients with essential hypertension. No difference in cell number or in the elastic properties was observed among the 4 groups of subjects. In conclusion, our data demonstrate for the first time that a pronounced activation of the renin-angiotensin-aldosterone system is associated with vascular smooth muscle cell hypertrophy in human hypertension in a manner similar to that found in animal models.
D Rizzoni; E Porteri; D Guefi; A Piccoli; M Castellano; G Pasini; M L Muiesan; M J Mulvany; E A Rosei
Related Documents :
4591034 - Attenuated vasodilator responses to k+ in essential hypertensive men.
8815854 - Extent of autonomic activation following cerebral ischemia is different in hypertensive...
8903654 - Relationship between albumin excretion rate, ambulatory blood pressure and left ventric...
7261534 - Refractory hypertension in an otherwise healthy adolescent.
9877474 - Nocturnal evolution of respiratory effort in obstructive sleep apnoea syndrome: influen...
8675254 - High sodium sensitivity implicates nocturnal hypertension in essential hypertension.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension     Volume:  35     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-09     Completed Date:  2000-05-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-5     Citation Subset:  IM    
Chair of Internal Medicine, Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arteries / pathology*,  physiopathology
Blood Pressure
Cell Size
Hypertension, Renovascular / pathology*,  physiopathology
Skin / blood supply
Vascular Resistance

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Shear stress-induced release of prostaglandin H(2) in arterioles of hypertensive rats.
Next Document:  Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelia...