Document Detail

Cellular heterogeneity and drug resistance in two ovarian adenocarcinoma cell lines derived from a single patient.
MedLine Citation:
PMID:  3583449     Owner:  NLM     Status:  MEDLINE    
Two ovarian cell lines were derived from the ascites of a patient before and after the onset of resistance to chemotherapy involving cis-platinum, chlorambucil and 5-fluorouracil. Characterization of these lines shows them to have various features in common and some significant differences. Cytologically the lines cannot be distinguished and they both contain high concentrations of oestrogen receptor. However, they do differ with respect to their growth characteristics, karyotype, glutathione content and sensitivity to cis-platinum. The karyotypes of the 2 lines show several marker chromosomes in common but the resistant line contained a chromosome 8 and a 17 which were absent from the earlier sensitive line. This suggests a clonal origin with subsequent divergence to a heterogeneous population.
C R Wolf; I P Hayward; S S Lawrie; K Buckton; M A McIntyre; D J Adams; A D Lewis; A R Scott; J F Smyth
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  39     ISSN:  0020-7136     ISO Abbreviation:  Int. J. Cancer     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-23     Completed Date:  1987-07-23     Revised Date:  2007-07-24    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / drug therapy*,  genetics,  pathology
Cell Line
Chromosome Aberrations
Drug Resistance
Glutathione / metabolism
Ovarian Neoplasms / drug therapy*,  genetics,  pathology
Receptors, Estrogen / analysis
Receptors, Progesterone / analysis
Reg. No./Substance:
0/Receptors, Estrogen; 0/Receptors, Progesterone; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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