Document Detail

Cellular events during early formation of yolk-sac-derived teratomas.
MedLine Citation:
PMID:  7142899     Owner:  NLM     Status:  MEDLINE    
A sequential morphological study of the initial cellular events in teratoma induction by displaced visceral yolk sac after foetectomy in rats was undertaken. This study led to the observation that apart from proliferation of cells displaying definite endodermal or mesodermal characteristics, a population of poorly differentiated cells appeared some days after the surgical procedure. It is very likely that these poorly differentiated cell are stem cells from which differentiated structures originate afterwards by a process of redifferentiation. The development of granulation tissue rich in capillaries seems to enhance this process. Similarities and differences with blastema formation are discussed.
H Sobis; L van Hove; M Vandeputte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of embryology and experimental morphology     Volume:  70     ISSN:  0022-0752     ISO Abbreviation:  J Embryol Exp Morphol     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1983-01-07     Completed Date:  1983-01-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906439     Medline TA:  J Embryol Exp Morphol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  225-40     Citation Subset:  IM    
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MeSH Terms
Cell Count
Cell Differentiation
Cell Division
Endoderm / ultrastructure
Mesoderm / ultrastructure
Microscopy, Electron
Neoplasms, Experimental / embryology
Rats, Inbred Strains
Teratoma / embryology*,  ultrastructure
Time Factors
Yolk Sac / ultrastructure

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