Document Detail


Cellular, enzymatic, and genetic factors in the pathogenesis of abdominal aortic aneurysms.
MedLine Citation:
PMID:  2537434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aneurysms of the abdominal aorta occur with atherosclerosis or connective tissue disorders. Changes of three components of aortic media, smooth muscle cells, elastin, and collagen, which could contribute to medial weakening, are discussed. Smooth muscle cells cultured from the aging abdominal aorta (normal, atherosclerotic, or aneurysmal) have limited replicative potential at five to six cell doublings, whereas cells from aneurysmal thoracic aorta undergo more than 20 cell doublings in culture. The elastin content is much reduced in aneurysms and this is associated with an increase in elastase activity of medial homogenates to 17.8 U/ng of deoxyribonucleic acid (DNA) compared with 8.3 and 4.4 U/ng of DNA in atherosclerotic and normal aorta, respectively. An elastinolytic enzyme has been purified from aneurysmal aorta and appears to have different properties from human leukocyte elastase. Ruptured aneurysms are associated with an increased total collagenase activity but the increase could be stimulated by, or result from, an influx of inflammatory cells and does not necessarily have a causal significance. In patients with a family history of aneurysm there appears to be a decreased content of type III collagen in aortic media: 24% +/- 4% compared with 32% +/- 5% in most aneurysms. Familial aneurysms are most common in women, and preliminary results suggest that a polymorphic variant of the type III collagen gene, defined by restriction enzyme digest, may be associated with aneurysmal disease in women. The genetic approach may define causal mechanisms predisposing patients to aneurysmal dilatation.
Authors:
J Powell; R M Greenhalgh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of vascular surgery     Volume:  9     ISSN:  0741-5214     ISO Abbreviation:  J. Vasc. Surg.     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1989-03-27     Completed Date:  1989-03-27     Revised Date:  2012-10-03    
Medline Journal Info:
Nlm Unique ID:  8407742     Medline TA:  J Vasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  297-304     Citation Subset:  IM    
Affiliation:
Department of Surgery, Charing Cross & Westminster Medical School, London, England.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aorta, Abdominal / analysis,  enzymology,  pathology
Aortic Aneurysm / enzymology,  etiology*,  genetics,  pathology
Collagen / analysis,  genetics
DNA / analysis
Elastin / analysis
Genotype
Humans
Lipids / analysis
Microbial Collagenase / analysis
Middle Aged
Muscle, Smooth, Vascular / pathology
Pancreatic Elastase / analysis
Phenotype
Chemical
Reg. No./Substance:
0/Lipids; 9007-34-5/Collagen; 9007-49-2/DNA; 9007-58-3/Elastin; EC 3.4.21.36/Pancreatic Elastase; EC 3.4.24.3/Microbial Collagenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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