Document Detail


Cellular dynamics during evagination of the thyroid primordium in the chick embryo.
MedLine Citation:
PMID:  11590592     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The thyroid forms as an outpouching of the ventral pharynx. Evidence supports the conclusion that formation of the thyroid pit is mediated by changes in the cytoskeleton that cause constriction of cell apices. However, it seems unlikely that a relatively flat epithelial sheet can be converted into a pit without either distortions of the surface or considerable rearrangement of cells to reduce surface area. Possible cellular rearrangements were investigated by tracing the movements of individual cells by using time-lapse video microscopy. Changes in shape of the primordium were investigated by marking with carbon and DiI and by scanning electron microscopy. Cell movements occurred only over short distances, mostly shifts relative to a neighbor, especially at the edge of the pit. Instead, cells rearranged into clusters that piled up at the edge of the pit and then tilted inside. Adjacent rings of pharyngeal cells were annexed by the growing thyroid, undergoing rearrangement into clusters, piling up at the edge, and moving inside the pit. The consequence was the formation of a series of shelf-like extensions within the cavity, representing successive generations of cell rings moving inside. These results have implications for the formation of other organs by evagination.
Authors:
G M Kinebrew; S R Hilfer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Anatomical record     Volume:  264     ISSN:  0003-276X     ISO Abbreviation:  Anat. Rec.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-08     Completed Date:  2001-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370540     Medline TA:  Anat Rec     Country:  United States    
Other Details:
Languages:  eng     Pagination:  146-56     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Affiliation:
Department of Biology, John Carroll University, University Heights, Ohio 44118, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Movement
Chick Embryo
Image Processing, Computer-Assisted
Microscopy, Electron, Scanning
Microscopy, Video
Models, Anatomic
Thyroid Gland / cytology,  embryology*

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