| Cellular dopamine is increased following exposure to a factor derived from immortalized striatal neurons [corrected]. | |
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MedLine Citation:
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PMID: 11078922 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A factor obtained from an immortalized hybrid monoclonal cell line (X61) of striatal origin is capable of increasing the dopamine content of hybrid, monoclonal cells expressing a dopaminergic phenotype (MN9D) and of aggregate cultures containing primary dopaminergic neurons. The factor is a protein smaller than 100 kDa and appears to be different than a number of other trophic agents with effects on the dopaminergic neuron. The effect on dopamine content appears to be specific to centrally-derived neuronal elements; the protein having no effect on the dopamine content of PC12 cells. Given that parkinsonian symptoms are only apparent following degeneration of a substantial portion of the mesencephalic dopaminergic cell population, activity capable of increasing dopamine content of the surviving cells may represent an interesting candidate therapeutic agent. |
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Authors:
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A Heller; A Freeney; S Hessefort; M Villereal; L Won |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 295 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-01-09 Completed Date: 2001-01-09 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: IRELAND |
Other Details:
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Languages: eng Pagination: 1-4 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, 947 East 58th Street, IL 60637, USA. effe@midway.uchicago.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Corpus Striatum
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cytology Dopamine / metabolism* Humans Hybrid Cells Mesencephalon / cytology, drug effects*, metabolism Nerve Growth Factors / isolation & purification, pharmacology*, therapeutic use Neurons / drug effects*, metabolism Parkinson Disease / drug therapy, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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MH-28942/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors |
| Comments/Corrections | |
Erratum In:
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Neurosci Lett 2001 Jan 19;297(3):216 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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