Document Detail

Cellular dopamine is increased following exposure to a factor derived from immortalized striatal neurons [corrected].
MedLine Citation:
PMID:  11078922     Owner:  NLM     Status:  MEDLINE    
A factor obtained from an immortalized hybrid monoclonal cell line (X61) of striatal origin is capable of increasing the dopamine content of hybrid, monoclonal cells expressing a dopaminergic phenotype (MN9D) and of aggregate cultures containing primary dopaminergic neurons. The factor is a protein smaller than 100 kDa and appears to be different than a number of other trophic agents with effects on the dopaminergic neuron. The effect on dopamine content appears to be specific to centrally-derived neuronal elements; the protein having no effect on the dopamine content of PC12 cells. Given that parkinsonian symptoms are only apparent following degeneration of a substantial portion of the mesencephalic dopaminergic cell population, activity capable of increasing dopamine content of the surviving cells may represent an interesting candidate therapeutic agent.
A Heller; A Freeney; S Hessefort; M Villereal; L Won
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  295     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2001-01-09     Completed Date:  2001-01-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  1-4     Citation Subset:  IM    
Department of Neurobiology, Pharmacology and Physiology, The University of Chicago, 947 East 58th Street, IL 60637, USA.
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MeSH Terms
Corpus Striatum / cytology
Dopamine / metabolism*
Hybrid Cells
Mesencephalon / cytology,  drug effects*,  metabolism
Nerve Growth Factors / isolation & purification,  pharmacology*,  therapeutic use
Neurons / drug effects*,  metabolism
Parkinson Disease / drug therapy,  metabolism
Grant Support
Reg. No./Substance:
0/Nerve Growth Factors
Erratum In:
Neurosci Lett 2001 Jan 19;297(3):216

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