Document Detail

Cellular trans-differentiation and morphogenesis toward the lymphatic lineage in regenerative medicine.
MedLine Citation:
PMID:  20836656     Owner:  NLM     Status:  In-Data-Review    
Lymphedema is a medically irresolvable condition. The lack of therapies addressing lymphatic vessel dysfunction suggests that improved understanding of lymphatic cell differentiation and vessel maturation processes is key to the development of novel, regenerative medicine, and tissue engineering approaches. In this review we provide an overview of lymphatic characterization markers and morphology in development. Further, we describe multiple differentiation processes of the lymphatic system during embryonic, postnatal, and pathogenic development. Using the example of pathogenic Kaposi's sarcoma-associated herpes infection, we illustrate the involvement of the Notch and PI3K pathways for lymphatic transdifferentiation. We also discuss the plasticity of certain cell types and biofactors that enable transdifferentiation toward the lymphatic lineage. Here we argue the importance of pathway-associated induction factors for lymphatic transdifferentiation, including growth factors such as vascular endothelial growth factor receptor-C and interleukins, and the involvement of extracellular matrix characteristics and dynamics for morphological functionality.
Filip Laco; Mary Helen Grant; David J Flint; Richard A Black
Related Documents :
7593136 - Correlation of differentiation-inducing activity of retinoids on human leukemia cell li...
7957886 - The calpain-calpastatin system is regulated differently during human neuroblastoma cell...
6684716 - Effects of inducers of erythroid differentiation of human leukemia k562 cells on vincri...
2428876 - Regulated expression of the mac-1, lfa-1, p150,95 glycoprotein family during leukocyte ...
2935896 - Stress-related impairments in cellular immunity.
25290396 - The immunological meaning of thy-1-negative nk cells.
Publication Detail:
Type:  Journal Article     Date:  2010-10-29
Journal Detail:
Title:  Stem cells and development     Volume:  20     ISSN:  1557-8534     ISO Abbreviation:  Stem Cells Dev.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197107     Medline TA:  Stem Cells Dev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  181-95     Citation Subset:  IM    
1 Department of Bioengineering, University of Strathclyde , Glasgow, Scotland, United Kingdom .
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Reactive oxygen species mediate oxidized low-density lipoprotein-induced inhibition of oct-4 express...
Next Document:  Enhanced neuropeptide Y synthesis during intermittent hypoxia in the rat adrenal medulla: role of re...