Document Detail

Cellular differentiation and development of pyloric mucosal metaplasia in the human gall-bladder.
MedLine Citation:
PMID:  8726849     Owner:  NLM     Status:  MEDLINE    
The development of pyloric mucosal metaplasia (PMM) with regard to cellular differentiation in the human gallbladder was studied by mucin staining (paradoxical concanavalin A (Con A), galactose oxidase-Schiff (GOS) and alcian blue (pH 2.5) PAS (AB-PAS) and immunohistochemistry (pepsinogen II (PgII) and SH-9, and proliferating cell nuclear antigen (PCNA). PMM was divided into three stages of development by three-dimensional (3D) computer graphic reconstruction analysis. In the early stage, a transitional zone of PCNA positive cells was observed between areas of SH-9 and/or GOS reactive cells and class III and/or Pg II positive cells in flat monolayered epithelium. In the middle stage, shallow pits became apparent as areas enlarged, with these becoming deeper in the advanced stage, whereby SH-9 and/or GOS reactive cells and class III and/or Pg II positive cells were observed at the upper and lower portion of the pits, respectively, with PCNA-positive cells forming a narrow zone between the two cell populations. Consequently, the structure of PMM gradually resembles that of the normal gastric pyloric mucosa.
M Shimizu; K Kitoh; Y Fujimitsu; K Inada; M Ichinose; K Miki; K Yamao; S Nakazawa; M Shamoto; M Tatematsu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pathology international     Volume:  46     ISSN:  1320-5463     ISO Abbreviation:  Pathol. Int.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1997-01-21     Completed Date:  1997-01-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9431380     Medline TA:  Pathol Int     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  261-6     Citation Subset:  IM    
Laboratory of Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.
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MeSH Terms
Cell Differentiation / physiology
Gallbladder / immunology,  pathology*,  surgery
Image Processing, Computer-Assisted
Metaplasia / immunology,  pathology*
Middle Aged
Models, Biological
Mucous Membrane / immunology,  pathology
Pylorus / immunology,  pathology*,  surgery
Time Factors

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