Document Detail


Cellular defense of the avian respiratory system: dose-response relationship and duration of response in intratracheal stimulation of avian respiratory phagocytes by a Pasteurella multocida bacterin.
MedLine Citation:
PMID:  8257367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In experiments analyzing dose-response, intratracheal inoculation of chickens with 10(8) and 10(9) avirulent Pasteurella multocida organisms induced the migration within 24 hr of large numbers of respiratory lavage cells (RLC) with increased phagocytic proportions and phagocytic capacity. Doses from 10(4) to 10(7) organisms per bird resulted in elevated numbers of RLCs that were not significantly higher (P > 0.05) than values of uninoculated or mock-inoculated control chickens. When analyzing the duration of response, we found that inoculation with 10(9) organisms resulted in significantly higher (P < 0.05) numbers of RLCs for 63 to 89 hr without significant elevation in phagocytic proportion and capacity. The numbers of RLCs were elevated, although not significantly (P > 0.05), up to 11 days after inoculation. These results indicate that RLCs migrate to the respiratory tract only in response to a relatively high number of stimulating bacterial organisms and that the duration of response is relatively short. Although there were elevated numbers of RLCs beyond 89 hours after stimulation, the question remains as to whether these cells would enhance nonspecific defense of the respiratory system of chickens.
Authors:
T E Toth; P B Siegel
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Avian diseases     Volume:  37     ISSN:  0005-2086     ISO Abbreviation:  Avian Dis.     Publication Date:    1993 Jul-Sep
Date Detail:
Created Date:  1994-01-11     Completed Date:  1994-01-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370617     Medline TA:  Avian Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  756-62     Citation Subset:  IM    
Affiliation:
College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg 24061.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bacterial Vaccines / administration & dosage
Bronchoalveolar Lavage Fluid / cytology
Chickens / immunology*
Dose-Response Relationship, Immunologic
Immunity, Cellular*
Male
Pasteurella multocida / immunology*,  pathogenicity
Phagocytes / immunology
Phagocytosis
Respiratory System / immunology*
Trachea
Virulence
Chemical
Reg. No./Substance:
0/Bacterial Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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