Document Detail


Cellular death by apoptosis in some radiosensitive and radioresistant mammalian tissues.
MedLine Citation:
PMID:  6317989     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A number of facts suggest that chromatin autodigestion, occurring in the early phase of apoptosis, is carried out by an enzymatic system, composed of an endonuclease and a protease, which yields oligonucleosomic chromatin fragments. Though this enzymatic system appears to be present in most mammalian cell nuclei, radiation-induced apoptosis takes place, with a high frequency, only in cell populations having less well-developed nuclear matrices, such as lymphoid cells. Moreover, apoptosis seems to occur in a different manner in cells with less well-developed nuclear matrices (radiosensitive cells) compared with cells that contain dense nuclear matrices (radioresistant cells). Thus, dying lymphocytes progressively release their degraded chromatin from nuclei, without displaying the cellular budding and formation of apoptotic bodies. Nevertheless, apoptosis remains the main cause of cell death and cell depletion in irradiated lymphoid tissues. In contrast, the process of cellular budding and formation of apoptotic bodies appears to be specific for cells having well-developed nuclear matrix, such as those from small intestine and liver. However, in these tissues the frequency of apoptosis is relatively low and cannot be considered as the main cause of radiation-induced tissue involution.
Authors:
D Suciu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of theoretical biology     Volume:  105     ISSN:  0022-5193     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-02-24     Completed Date:  1984-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  391-401     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Nucleus / ultrastructure
Cell Survival* / radiation effects
Chromatin / metabolism
Chromosomal Proteins, Non-Histone / physiology
DNA
Endonucleases / metabolism
Humans
Interphase
Lymphoid Tissue / metabolism,  radiation effects,  ultrastructure
Radiation Tolerance*
Chemical
Reg. No./Substance:
0/Chromatin; 0/Chromosomal Proteins, Non-Histone; 9007-49-2/DNA; EC 3.1.-/Endonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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