| Cellular and cytokine changes in the alveolar environment among immunocompromised patients during Pneumocystis jirovecii infection. | |
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MedLine Citation:
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PMID: 20470237 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Limited data exist on the cytokine and cellular changes in the alveolar environment in immunocompromised patients during Pneumocystis jirovecii infection. A cellular and a cytokine analysis were performed on bronchoalveolar lavage (BAL) samples from three groups of patients, i.e., an initial study group of 64 immunocompromised P. jirovecii-positive individuals and two control groups of P. jirovecii-negative patients who had been or not immunosuppressed (65 patients). The results were related to alveolar dilution as determined by urea measurement. Compared with non-infected groups, P. jirovecii-infected patients had a lower level of alveolar macrophages (AM), particularly those with high burdens of P. jirovecii. Alveolar macrophages over-expressed the Dectin-1 receptor, which was largely implicated in P. jirovecii clearance. The alveolar CD8+T and CD4+T lymphocyte counts were increased and an inverse correlation was observed between the alveolar CD4+ cell count and the P. jirovecii burden. Although the alveolar IL-6 level was considerably increased, alveolar IL-17, IL-10, TNF-α, TGF-β concentrations of P. jirovecii patients were not different from the control groups. Changes in the pulmonary environment were also highlighted during P. jirovecii colonization. Our study suggests that there is a correlation between the P. jirovecii burden in the alveolus (from colonization to a high P. jirovecii burden), and the degree of impairment of the alveolar immune response. |
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Authors:
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Xavier Iriart; Benoit Witkowski; Caroline Courtais; Sarah Abbes; Jean Tkaczuk; Monique Courtade; Sophie Cassaing; Judith Fillaux; Antoine Blancher; Jean-François Magnaval; Bernard Pipy; Antoine Berry |
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Publication Detail:
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Type: Journal Article Date: 2010-05-17 |
Journal Detail:
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Title: Medical mycology : official publication of the International Society for Human and Animal Mycology Volume: 48 ISSN: 1460-2709 ISO Abbreviation: Med. Mycol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9815835 Medline TA: Med Mycol Country: England |
Other Details:
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Languages: eng Pagination: 1075-87 Citation Subset: IM |
Affiliation:
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Service de Parasitologie Mycologie, Centre Hospitalier Universitaire de Toulouse, H ô pital Rangueil, Toulouse, France. xabierlete@yahoo.fr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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