Document Detail

Cellular complexity captured in durable silica biocomposites.
MedLine Citation:
PMID:  23045634     Owner:  NLM     Status:  MEDLINE    
Tissue-derived cultured cells exhibit a remarkable range of morphological features in vitro, depending on phenotypic expression and environmental interactions. Translation of these cellular architectures into inorganic materials would provide routes to generate hierarchical nanomaterials with stabilized structures and functions. Here, we describe the fabrication of cell/silica composites (CSCs) and their conversion to silica replicas using mammalian cells as scaffolds to direct complex structure formation. Under mildly acidic solution conditions, silica deposition is restricted to the molecularly crowded cellular template. Inter- and intracellular heterogeneity from the nano- to macroscale is captured and dimensionally preserved in CSCs following drying and subjection to extreme temperatures allowing, for instance, size and shape preserving pyrolysis of cellular architectures to form conductive carbon replicas. The structural and behavioral malleability of the starting material (cultured cells) provides opportunities to develop robust and economical biocomposites with programmed structures and functions.
Bryan Kaehr; Jason L Townson; Robin M Kalinich; Yasmine H Awad; B S Swartzentruber; Darren R Dunphy; C Jeffrey Brinker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-08
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-01-07     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17336-41     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Microscopy, Electron, Transmission
Silicon Dioxide*
Tissue Scaffolds*
Grant Support
Reg. No./Substance:
7631-86-9/Silicon Dioxide
Comment In:
Nat Nanotechnol. 2012 Dec;7(12):777-8   [PMID:  23212419 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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