Document Detail


Cellular complexity captured in durable silica biocomposites.
MedLine Citation:
PMID:  23045634     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tissue-derived cultured cells exhibit a remarkable range of morphological features in vitro, depending on phenotypic expression and environmental interactions. Translation of these cellular architectures into inorganic materials would provide routes to generate hierarchical nanomaterials with stabilized structures and functions. Here, we describe the fabrication of cell/silica composites (CSCs) and their conversion to silica replicas using mammalian cells as scaffolds to direct complex structure formation. Under mildly acidic solution conditions, silica deposition is restricted to the molecularly crowded cellular template. Inter- and intracellular heterogeneity from the nano- to macroscale is captured and dimensionally preserved in CSCs following drying and subjection to extreme temperatures allowing, for instance, size and shape preserving pyrolysis of cellular architectures to form conductive carbon replicas. The structural and behavioral malleability of the starting material (cultured cells) provides opportunities to develop robust and economical biocomposites with programmed structures and functions.
Authors:
Bryan Kaehr; Jason L Townson; Robin M Kalinich; Yasmine H Awad; B S Swartzentruber; Darren R Dunphy; C Jeffrey Brinker
Related Documents :
23921684 - Comparative analysis of osteogenic/chondrogenic differentiation potential in primary li...
23788904 - New fluphenazine analogues as inhibitors of p-glycoprotein in human lymphocyte cultures.
23554774 - Cyclosporine a stimulated hair growth from mouse vibrissae follicles in an organ cultur...
1070514 - Thymidine and uridine degradation by nucleosidases of cultured human lymphoblastoid cells.
11736644 - Hydrogen peroxide-induced production of a 40 kda immunoreactive thyroglobulin fragment ...
11239484 - Regulation of mitochondrial respiration by nitric oxide inhibition of cytochrome c oxid...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-10-08
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  109     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-24     Completed Date:  2013-01-07     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17336-41     Citation Subset:  IM    
Affiliation:
Advanced Materials Laboratory, Sandia National Laboratories, Albuquerque, NM 87106, USA. bjkaehr@sandia.gov
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Microscopy, Electron, Transmission
Silicon Dioxide*
Tissue Scaffolds*
Chemical
Reg. No./Substance:
7631-86-9/Silicon Dioxide
Comments/Corrections
Comment In:
Nat Nanotechnol. 2012 Dec;7(12):777-8   [PMID:  23212419 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Energetic costs of cellular computation.
Next Document:  Active, motor-driven mechanics in a DNA gel.