| Cellular complexity captured in durable silica biocomposites. | |
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MedLine Citation:
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PMID: 23045634 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tissue-derived cultured cells exhibit a remarkable range of morphological features in vitro, depending on phenotypic expression and environmental interactions. Translation of these cellular architectures into inorganic materials would provide routes to generate hierarchical nanomaterials with stabilized structures and functions. Here, we describe the fabrication of cell/silica composites (CSCs) and their conversion to silica replicas using mammalian cells as scaffolds to direct complex structure formation. Under mildly acidic solution conditions, silica deposition is restricted to the molecularly crowded cellular template. Inter- and intracellular heterogeneity from the nano- to macroscale is captured and dimensionally preserved in CSCs following drying and subjection to extreme temperatures allowing, for instance, size and shape preserving pyrolysis of cellular architectures to form conductive carbon replicas. The structural and behavioral malleability of the starting material (cultured cells) provides opportunities to develop robust and economical biocomposites with programmed structures and functions. |
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Authors:
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Bryan Kaehr; Jason L Townson; Robin M Kalinich; Yasmine H Awad; B S Swartzentruber; Darren R Dunphy; C Jeffrey Brinker |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-10-08 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 109 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-24 Completed Date: 2013-01-07 Revised Date: 2013-04-23 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 17336-41 Citation Subset: IM |
Affiliation:
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Advanced Materials Laboratory, Sandia National Laboratories, Albuquerque, NM 87106, USA. bjkaehr@sandia.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Microscopy, Electron, Transmission Silicon Dioxide* Tissue Scaffolds* |
| Chemical | |
Reg. No./Substance:
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7631-86-9/Silicon Dioxide |
| Comments/Corrections | |
Comment In:
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Nat Nanotechnol. 2012 Dec;7(12):777-8
[PMID:
23212419
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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