Document Detail

Cellular changes in the spleens of mice infected with Sarcocystis muris.
MedLine Citation:
PMID:  3147239     Owner:  NLM     Status:  MEDLINE    
Cellular changes in the spleens of mice infected with Sarcocystis muris have been studied. Immunofluorescent staining for B and T cells and alpha-naphthyl acetate esterase (ANAE) staining for macrophages combined with histological studies revealed marked changes in the populations and distributions of all three cell types. Infection was accompanied by a marked splenomegaly, attributable mainly to widespread hyperplasia of the white pulp. Following infection there was an increase in the relative proportions of B cells (i.e. surface immunoglobulin+) and ANAE+ cells and a decrease in the proportion of T cells (i.e. Thy 1.2+). There was also a progressive accumulation of immunoglobulin-containing cells in the periarteriolar lymphocytic sheaths. Splenomegaly was most pronounced 20 days after infection. At this time there were 9.3 times as many B cells, 3.7 times as many T cells and 16.6 times as many ANAE+ cells as in uninfected mice.
H S Gill; W A Charleston; K M Moriarty
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology and cell biology     Volume:  66 ( Pt 5-6)     ISSN:  0818-9641     ISO Abbreviation:  Immunol. Cell Biol.     Publication Date:    1988 Oct-Dec
Date Detail:
Created Date:  1989-04-05     Completed Date:  1989-04-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8706300     Medline TA:  Immunol Cell Biol     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  337-43     Citation Subset:  IM    
Department of Veterinary Pathology and Public Health, Massey University, Palmerston North, New Zealand.
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MeSH Terms
B-Lymphocytes / immunology
Cell Count
Organ Size
Sarcocystosis / immunology*,  pathology
Spleen / immunology*,  pathology
T-Lymphocytes / immunology

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