Document Detail

Cellular basis of aging in the mammalian heart.
MedLine Citation:
PMID:  1822029     Owner:  NLM     Status:  MEDLINE    
This review is concerned with the functional and structural changes occurring in the aging heart. These changes were investigated in an integrated fashion in Fischer 344 rats at 4, 12, 20, and 29 months after birth. Mean arterial pressure, left ventricular systolic and end-diastolic pressures, as well as stroke volume remained substantially constant up to 20 months. At 29 months, however, end-diastolic pressure was significantly increased, and dP/dt and stroke volume were depressed. Focal areas of interstitial and replacement fibrosis were markedly increased at 20 and 29 months, mostly in the subendocardial region of the ventricular wall. Also the aggregate number of mononucleated and binucleated cells in the left ventricle as a function of age was determined. The number of mononucleated cells increased up to 20 months but decreased thereafter; the binucleated cells showed a reversed pattern. The aging process of the heart involves a number of interrelated events including biochemical, electrical, mechanical and structural modifications. With aging and senescence, left ventricular failure develops in the Fischer rat model, and a similar process may occur in the human as well.
P Anversa; J M Capasso
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scanning microscopy     Volume:  5     ISSN:  0891-7035     ISO Abbreviation:  Scanning Microsc.     Publication Date:  1991 Dec 
Date Detail:
Created Date:  1992-08-24     Completed Date:  1992-08-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8704616     Medline TA:  Scanning Microsc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1065-73; discussion 1073-4     Citation Subset:  IM    
Department of Medicine, New York Medical College, Valhalla 10595.
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MeSH Terms
Aging / pathology*
Cell Count
Heart / physiology
Myocardium / cytology,  pathology*
Rats, Inbred F344
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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