| Cellular bases for the lipid-related aspects of preeclampsia. | |
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MedLine Citation:
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PMID: 12710909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipid accumulation - in hepatoytes (both subclinically and in acute fatty liver of pregnancy), in the endothelium of placental vessels ("acute atherosis"), and in the bloodstream - has been well established to be a consequence of preeclampsia. Hyperlipidemia (specifically hypertriglyceridemia) has been demonstrated to be a risk factor for the development of preeclampsia. These lipid-related aspects of preeclampsia may appear unrelated, but all are here demonstrated to provide evidence for a causative role for endothelin in the etiology of preeclampsia. Evidence for the potential of endothelin to cause lipid accumulation in hepatocytes and in endothelial cells, by means of activating G protein cascades in these cells, is presented. The capacity of typical free fatty acid constituents of triglycerides to "drive" interacellular G protein cascade-related events is also discussed - which, in this scheme, offers a plausible explanation for hypertriglyceridemia's role as a risk factor for developing preeclampsia. Additional evidence is provided which substantiates endothelin's capacity to cause most of the observed aberrations known to occur in preeclampsia. |
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Authors:
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Charles G Coffey |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 60 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 2003 May |
Date Detail:
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Created Date: 2003-04-24 Completed Date: 2004-01-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: Scotland |
Other Details:
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Languages: eng Pagination: 716-9 Citation Subset: IM |
Affiliation:
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Golconda, Illinois, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fatty Liver
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complications Female Humans Hyperlipidemias / complications* Pre-Eclampsia / etiology*, metabolism Pregnancy Pregnancy Complications |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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