Document Detail


Cellular ageing related proteins secreted by human fibroblasts.
MedLine Citation:
PMID:  1722005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fibroblast secreted proteins participate in the formation of extracellular matrix. Extracellular matrix affects growth factor action, mediates cell adhesion and supports cell growth. Structural and quantitative characteristics of secreted proteins are modified in a similar manner, during both in vivo and in vitro cellular ageing. Such ageing related modifications may either be directly controlled by primary ageing causes, or evolve from a reformation of the extracellular matrix induced by a few ageing defects in key proteins such as fibronectin. They may result in the further inhibition of cell adhesion, cell stimulation by growth factors and, eventually, of cell proliferative ability.
Authors:
C S Eleftheriou; N B Trakas; S J Tzartos
Related Documents :
22996665 - Conditional gata2 inactivation results in hsc loss and lymphatic mispatterning.
18228495 - Preparation of extracellular matrices produced by cultured and primary fibroblasts.
24469165 - Lymph node transplantation results in spontaneous lymphatic reconnection and restoratio...
24037655 - Cyclooxygenase inhibitors reduce biofilm formation and yeast-hypha conversion of flucon...
21212315 - The inhibitory effects of quaternary ammonium methacrylates on soluble and matrix-bound...
8466625 - Proteoglycans on endothelial cells present adhesion-inducing cytokines to leukocytes.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mutation research     Volume:  256     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1991 Mar-Nov
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  127-38     Citation Subset:  IM    
Affiliation:
Hellenic Pasteur Institute, Athens, Greece.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Cell Adhesion
Cell Aging*
Extracellular Matrix / metabolism
Extracellular Matrix Proteins / secretion*
Fibroblasts / cytology*,  secretion
Growth Substances / metabolism
Humans
Chemical
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Growth Substances

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Protein synthesis and the components of protein synthetic machinery during cellular aging.
Next Document:  Actin cytoskeletal network in aging and cancer.