Document Detail

Cellular ageing related proteins secreted by human fibroblasts.
MedLine Citation:
PMID:  1722005     Owner:  NLM     Status:  MEDLINE    
Fibroblast secreted proteins participate in the formation of extracellular matrix. Extracellular matrix affects growth factor action, mediates cell adhesion and supports cell growth. Structural and quantitative characteristics of secreted proteins are modified in a similar manner, during both in vivo and in vitro cellular ageing. Such ageing related modifications may either be directly controlled by primary ageing causes, or evolve from a reformation of the extracellular matrix induced by a few ageing defects in key proteins such as fibronectin. They may result in the further inhibition of cell adhesion, cell stimulation by growth factors and, eventually, of cell proliferative ability.
C S Eleftheriou; N B Trakas; S J Tzartos
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Mutation research     Volume:  256     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:    1991 Mar-Nov
Date Detail:
Created Date:  1992-02-06     Completed Date:  1992-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  127-38     Citation Subset:  IM    
Hellenic Pasteur Institute, Athens, Greece.
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MeSH Terms
Cell Adhesion
Cell Aging*
Extracellular Matrix / metabolism
Extracellular Matrix Proteins / secretion*
Fibroblasts / cytology*,  secretion
Growth Substances / metabolism
Reg. No./Substance:
0/Extracellular Matrix Proteins; 0/Growth Substances

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