| Cellular ageing and the actin cytoskeleton. | |
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MedLine Citation:
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PMID: 22094429 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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For some time the view that the actinactin cytoskeletoncytoskeleton acts primarily as a scaffold, to be assembled in response to a signaling cascade as an end point in the pathway, has prevailed. However, it is now clear that the dynamic nature of the cytoskeletoncytoskeleton is linked to downstream signaling events that further modulate cellular activity, and which can determine cell fate. Examples of this lie within the regulation of programmed cell death, the maintenance of homeostasis and the process of cellular ageing. In yeast the actinactin cytoskeletoncytoskeleton has been shown to interact directly with signaling pathways known to be important in the regulation of both ageing and cell death. For example it has been discovered that the level of damage sustained by the actinactin cytoskeletoncytoskeleton under conditions of oxidative stressoxidative stress is directly linked to apoptosis. Further evidence comes from the finding that actinactin based propulsion mechanisms are required for the inheritance of mitochondriamitochondria and anti-ageing factors into newly formed cells. In addition to this actinactin is known to directly influence the formation of protein aggregations. In this chapter we will discuss these points and postulate as to their significance with respect to the maintenance of cellular homeostasis. |
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Authors:
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David Amberg; Jane E Leadsham; Vasillios Kotiadis; Campbell W Gourlay |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Sub-cellular biochemistry Volume: 57 ISSN: 0306-0225 ISO Abbreviation: Subcell. Biochem. Publication Date: 2012 |
Date Detail:
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Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0316571 Medline TA: Subcell Biochem Country: England |
Other Details:
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Languages: eng Pagination: 331-52 Citation Subset: IM |
Affiliation:
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Department of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY, USA, ambergd@upstate.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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