Document Detail


Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells.
MedLine Citation:
PMID:  22975873     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4(+) T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4(+) T cells form a virological synapse that allows highly efficient transmission of HIV-1 to the target CD4(+) T cells, in the absence of productive HIV-1 replication in the DCs. Immature and subsets of mature DCs show distinct patterns of HIV-1 replication and cell-to-cell transmission, depending upon the maturation stimulus that is used. The cellular and viral mechanisms that promote formation of the virological synapse have been the subject of intense study and the most recent progress is discussed here. Characterizing the cellular and viral factors that affect DC-mediated cell-to-cell transmission of HIV-1 to CD4(+) T cells is vitally important to understanding, and potentially blocking, the initial dissemination of HIV-1 in vivo.
Authors:
Christopher M Coleman; Corine St Gelais; Li Wu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  762     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2013  
Date Detail:
Created Date:  2012-09-14     Completed Date:  2013-01-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  109-30     Citation Subset:  IM    
Affiliation:
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA.
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MeSH Terms
Descriptor/Qualifier:
Dendritic Cells / immunology*
HIV Infections / immunology,  transmission*
HIV-1 / physiology
Humans
Virus Replication / immunology
Grant Support
ID/Acronym/Agency:
AI068493/AI/NIAID NIH HHS; AI078762/AI/NIAID NIH HHS; AI098524/AI/NIAID NIH HHS; R01 AI068493/AI/NIAID NIH HHS; R21 AI078762/AI/NIAID NIH HHS; R21 AI098524/AI/NIAID NIH HHS; R21 AI102822/AI/NIAID NIH HHS
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