| Cellular and viral mechanisms of HIV-1 transmission mediated by dendritic cells. | |
| | |
MedLine Citation:
|
PMID: 22975873 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Dendritic cells (DCs) play a key role in the initial infection and cell-to-cell transmission events that occur upon HIV-1 infection. DCs interact closely with CD4(+) T cells, the main target of HIV-1 replication. HIV-1 challenged DCs and target CD4(+) T cells form a virological synapse that allows highly efficient transmission of HIV-1 to the target CD4(+) T cells, in the absence of productive HIV-1 replication in the DCs. Immature and subsets of mature DCs show distinct patterns of HIV-1 replication and cell-to-cell transmission, depending upon the maturation stimulus that is used. The cellular and viral mechanisms that promote formation of the virological synapse have been the subject of intense study and the most recent progress is discussed here. Characterizing the cellular and viral factors that affect DC-mediated cell-to-cell transmission of HIV-1 to CD4(+) T cells is vitally important to understanding, and potentially blocking, the initial dissemination of HIV-1 in vivo. |
| | |
Authors:
|
Christopher M Coleman; Corine St Gelais; Li Wu |
Related Documents
:
|
23424063 - The smallest unit: effector and memory cd8(+) t cell differentiation on the single cell... 23374843 - Differentiation of human adipose-derived stem cells co-cultured with urothelium cell l... 7623623 - Suppression of mouse lymphocyte proliferation in vitro by naturally-occurring biflavono... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: Advances in experimental medicine and biology Volume: 762 ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 2013 |
Date Detail:
|
Created Date: 2012-09-14 Completed Date: 2013-01-14 Revised Date: 2013-02-20 |
Medline Journal Info:
|
Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: United States |
Other Details:
|
Languages: eng Pagination: 109-30 Citation Subset: IM |
Affiliation:
|
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Dendritic Cells
/
immunology* HIV Infections / immunology, transmission* HIV-1 / physiology Humans Virus Replication / immunology |
| Grant Support | |
ID/Acronym/Agency:
|
AI068493/AI/NIAID NIH HHS; AI078762/AI/NIAID NIH HHS; AI098524/AI/NIAID NIH HHS; R01 AI068493/AI/NIAID NIH HHS; R21 AI078762/AI/NIAID NIH HHS; R21 AI098524/AI/NIAID NIH HHS; R21 AI102822/AI/NIAID NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasmacytoid dendritic cells in HIV infection.
Next Document: Role of glycosphingolipids in dendritic cell-mediated HIV-1 trans-infection.