| Cellular Uptake and Intracellular Trafficking of Antisense and siRNA Oligonucleotides. | |
| | |
MedLine Citation:
|
PMID: 21992697 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Significant progress is being made concerning the development of oligonucleotides as therapeutic agents. Studies with antisense, siRNA, and other forms of oligonucleotides have shown promise in cellular and animal models and in some clinical studies. Nonetheless our understanding of how oligonucleotides function in cells and tissues is really quite limited. One major issue concerns the modes of uptake and intracellular trafficking of oligonucleotides, whether as 'free' molecules, or linked to various delivery moieties such as nanoparticles or targeting ligands. In this review we examine the recent literature on oligonucleotide internalization and subcellular trafficking in the context of current insights into the basic machinery for endocytosis and intracellular vesicular traffic. |
| | |
Authors:
|
Rudolph L Juliano; Xin Ming; Osamu Nakagawa |
Related Documents
:
|
18708157 - Cobalt induces oxidative stress in isolated liver mitochondria responsible for permeabi... 21145417 - Inhibition of macrophage inflammatory cytokine secretion by chylomicron remnants is dep... 20153717 - Hypoxia and mitochondrial oxidative metabolism. 20132737 - Over-expression of junb inhibits mitochondrial stress and cytotoxicity in human lymphom... 21289217 - Distinct macrophage phenotypes contribute to kidney injury and repair. 16785517 - Galectin-1-matured human monocyte-derived dendritic cells have enhanced migration throu... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-13 |
Journal Detail:
|
Title: Bioconjugate chemistry Volume: - ISSN: 1520-4812 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9010319 Medline TA: Bioconjug Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diversity of sex chromosome abnormalities in a cohort of 95 Indonesian patients with monosomy X.
Next Document: Biomonitoring of metals in the vicinity of Soma coal-fired power plant in western Anatolia, Turkey u...