Document Detail


Cellular Uptake of Covalent Poly(allylamine hydrochloride) Microcapsules and Its Influences on Cell Functions.
MedLine Citation:
PMID:  23008194     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The mechanism of the cellular uptake of polyelectrolyte microcapsules and its influences on the functions and toxicity of human SMCs are explored. The covalently assembled poly(allylamine hydrochloride)/glutaraldehyde microcapsules are easily ingested by SMCs mainly through macropinosis and caveolae-mediated endocytosis pathways. The capsules mainly disperse in cytoplasm without colocalization in early endosomes and cell nucleus. The results of gene chips reveal substantial and profound alternation of cell phenotypes and functions. Uptake of the microcapsules cause a slight decrease of cell viability, but leads to significant changes in cytoskeleton organization, cell cycle, as well as cell adhesion and migration ability.
Authors:
Bing Wang; Yuying Zhang; Zhengwei Mao; Changyou Gao
Related Documents :
25128424 - The cytotoxic activities of cardiac glycosides from streptocaulon juventas and the stru...
24687874 - Developmental origins and functions of stromal cells in the normal and diseased mammali...
24516164 - Differentiated human stem cells resemble fetal, not adult, β cells.
24503564 - Antioxidant enzymes regulate reactive oxygen species during pod elongation in pisum sat...
16619494 - Arising podosomal structures are associated with neoplastic cell morphological phenotyp...
6381654 - Transformation of fibre types in muscular dystrophies.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-24
Journal Detail:
Title:  Macromolecular bioscience     Volume:  -     ISSN:  1616-5195     ISO Abbreviation:  Macromol Biosci     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135941     Medline TA:  Macromol Biosci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
MOE of Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Single center comparative outcomes of the edwards sapien and medtronic melody transcatheter heart va...
Next Document:  Genetic variants in the catechol-o-methyltransferase gene are associated with impulsivity and execut...