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Cellular Responses to Hypoxia in the Pulmonary Circulation.
MedLine Citation:
PMID:  23795730     Owner:  NLM     Status:  Publisher    
Abstract Welsh, David J., and Andrew J. Peacock. Cellular responses to hypoxia in the pulmonary circulation. High Alt Med Biol 14:111-116, 2013.-Hypoxia can be defined as a reduction in available oxygen, whether in a whole organism or in a tissue or cell. It is a real life cause of pulmonary hypertension in humans both in terms of patients with chronic hypoxic lung disease and people living at high altitude. The effect of hypoxia on the pulmonary vasculature can be described in two ways; Hypoxic pulmonary vasoconstriction (HPV) (resulting from smooth muscle cell contraction) and pulmonary vascular remodelling (PVR) (resulting from pulmonary vascular cell proliferation). The pulmonary artery is made up of three resident cell types, the endothelial (intima), smooth muscle (media) and fibroblast (adventitia) cells. This review will examine the effects of hypoxia on the cells of the pulmonary vasculature and give an insight into the possible underlying mechanisms.
David J Welsh; Andrew J Peacock
Publication Detail:
Journal Detail:
Title:  High altitude medicine & biology     Volume:  14     ISSN:  1557-8682     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  111-116     Citation Subset:  -    
Scottish Pulmonary Vascular Unit, Regional Heart and Lung Center , Glasgow, United Kingdom .
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