| Cellular and molecular basis for the regulation of inflammation by TGF-beta. | |
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MedLine Citation:
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PMID: 20410014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transforming growth factor-beta (TGF-beta) has been shown to play an essential role in the suppression of inflammation, yet recent studies have revealed the positive roles of TGF-beta in inflammatory responses. For example, TGF-beta induces Foxp3-positive regulatory T cells (iTregs) in the presence of interleukin-2 (IL-2), while in the presence of IL-6, it induces pathogenic IL-17 producing Th17 cells. TGF-beta inhibits the proliferation of immune cells as well as cytokine production via Foxp3-dependent and -independent mechanisms. Little is known about molecular mechanisms involved in immune suppression via TGF-beta; however, Smad2/3 have been shown to play essential roles in Foxp3 induction as well as in IL-2 and IFN-gamma suppression, whereas Th17 differentiation is promoted via the Smad-independent pathway. Interaction between TGF-beta and other cytokine signaling is important in establishing the balance of immunity and tolerance. |
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Authors:
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Akihiko Yoshimura; Yu Wakabayashi; Tomoaki Mori |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-04-20 |
Journal Detail:
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Title: Journal of biochemistry Volume: 147 ISSN: 1756-2651 ISO Abbreviation: J. Biochem. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-03 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0376600 Medline TA: J Biochem Country: England |
Other Details:
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Languages: eng Pagination: 781-92 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. yoshimura@a6.keio.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Inflammation / immunology*, physiopathology Mice Signal Transduction / immunology Smad Proteins, Receptor-Regulated / physiology* T-Lymphocyte Subsets / physiology T-Lymphocytes, Regulatory / physiology Transforming Growth Factor beta / immunology*, metabolism, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Smad Proteins, Receptor-Regulated; 0/Transforming Growth Factor beta |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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