Document Detail

The cellular memory disc of reprogrammed cells.
MedLine Citation:
PMID:  23412894     Owner:  NLM     Status:  MEDLINE    
The crucial facts underlying the low efficiency of cellular reprogramming are poorly understood. Cellular reprogramming occurs in nuclear transfer, induced pluripotent stem cell (iPSC) formation, cell fusion, and lineage-switching experiments. Despite these advances, there are three fundamental problems to be addressed: (1) the majority of cells cannot be reprogrammed, (2) the efficiency of reprogramming cells is usually low, and (3) the reprogrammed cells developed from a patient's own cells activate immune responses. These shortcomings present major obstacles for using reprogramming approaches in customised cell therapy. In this Perspective, the author synthesises past and present observations in the field of cellular reprogramming to propose a theoretical picture of the cellular memory disc. The current hypothesis is that all cells undergo an endogenous and exogenous holographic memorisation such that parts of the cellular memory dramatically decrease the efficiency of reprogramming cells, act like a barrier against reprogramming in the majority of cells, and activate immune responses. Accordingly, the focus of this review is mainly to describe the cellular memory disc (CMD). Based on the present theory, cellular memory includes three parts: a reprogramming-resistance memory (RRM), a switch-promoting memory (SPM) and a culture-induced memory (CIM). The cellular memory arises genetically, epigenetically and non-genetically and affects cellular behaviours. [corrected].
Seyed Hadi Anjamrooz
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Stem cell reviews     Volume:  9     ISSN:  1558-6804     ISO Abbreviation:  Stem Cell Rev     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-29     Completed Date:  2013-09-05     Revised Date:  2013-11-07    
Medline Journal Info:
Nlm Unique ID:  101255952     Medline TA:  Stem Cell Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  190-209     Citation Subset:  IM    
Cellular and Molecular Research Center, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
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MeSH Terms
Cell Differentiation
Cell Lineage / immunology
Epigenesis, Genetic
Immunologic Memory*
Induced Pluripotent Stem Cells / cytology*,  physiology
Nuclear Transfer Techniques
Erratum In:
Stem Cell Rev. 2013 Oct;9(5):741

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