Document Detail

Cellular Localization of Inhibin alpha-subunit, PKB/Akt and FoxO3a proteins in the ovaries of minipigs.
MedLine Citation:
PMID:  17132910     Owner:  NLM     Status:  MEDLINE    
Experiments were conducted to examine the cellular localization of inhibin alpha-subunit, protein kinase B (PKB/Akt), and FoxO3a proteins in the ovaries of minipigs, Chinese Xiang pigs, by immunohistochemistry. The results indicated that inhibin alpha-subunits were localized in the granulosa cells of follicles at all stages but were not localized in corpora lutea. PKB was localized in the granulosa cells of primordial follicles and in the basal layers of the granulosa cells of preantral and antral follicles, but were not localized in atretic follicles and corpora lutea. FoxO3a was localized in the granulosa cells of follicles at all stages and was extensively localized in the cytoplasma of the luteinized granulosa cells of corpora lutea. Together, the stage- and cell-specific expression patterns of inhibin alpha-subunit, FoxO3a, and PKB suggest that these proteins might play potential roles in follicular development, atresia, and luteinization in the minipig.
Chunhua Meng; Fangxiong Shi; Zhenqi Zhou; Ruihua Huang; Gentao Liu; Gen Watanabe; Kazuyoshi Taya
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-29
Journal Detail:
Title:  The Journal of reproduction and development     Volume:  53     ISSN:  0916-8818     ISO Abbreviation:  J. Reprod. Dev.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-05-17     Completed Date:  2007-06-18     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  9438792     Medline TA:  J Reprod Dev     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Laboratory of Animal Reproduction, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, PR China.
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MeSH Terms
Cytoplasm / metabolism
Forkhead Transcription Factors / metabolism*
Granulosa Cells / metabolism
Immunohistochemistry / methods
Inhibins / metabolism*
Ovary / cytology*,  physiology
Proto-Oncogene Proteins c-akt / metabolism*
Swine, Miniature
Reg. No./Substance:
0/Forkhead Transcription Factors; 0/inhibin-alpha subunit; 57285-09-3/Inhibins; EC Proteins c-akt

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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