| Cellular functions of transient receptor potential channels. | |
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MedLine Citation:
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PMID: 20399884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Transient Receptor Potential channels are polymodal cellular sensors involved in a wide variety of cellular processes, mainly by increasing cellular Ca(2+). In this review we focus on the roles of these channels in: (i) cell death (ii) proliferation and differentiation and (iii) transmitter release. Cell death: Ca(2+) influx participates in apoptotic and necrotic cell death. The Ca(2+) permeability and high sensitivity of part of these channels to oxidative/metabolic stress make them important participants in cell death. Several examples are given. Transient Receptor Potential Melastatin 2 is activated by H(2)O(2), inducing cell death through an increase in cellular Ca(2+) and activation of Poly ADP-Ribose Polymerase. Exposure of cultured cortical neurons to oxygen-glucose deprivation, in vitro, causes cell death via cation influx, mediated by Transient Receptor Potential Melastatin 7. Metabolic stress constitutively activates the Ca(2+) permeable Transient Receptor Potential channels of Drosophila photoreceptor in the dark, potentially leading to retinal degeneration. Similar sensitivity to metabolic stress characterizes several mammalian Transient Receptor Potential Canonical channels. Proliferation and differentiation: The rise in cytosolic Ca(2+) induces cell growth, differentiation and proliferation via activation of several transcription factors. Activating a variety of store operated and Transient Receptor Potential channels cause a rise in cytosolic Ca(2+), making these channels components involved in proliferation and differentiation. Transmitter release: Transient Receptor Potential Melastatin 7 channels reside in synaptic vesicles and regulate neurotransmitter release by a mechanism that is not entirely clear. All the above features of Transient Receptor Potential channels make them crucial components in important, sometimes conflicting, cellular processes that still need to be explored. |
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Authors:
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Daniela Dadon; Baruch Minke |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2010-04-22 |
Journal Detail:
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Title: The international journal of biochemistry & cell biology Volume: 42 ISSN: 1878-5875 ISO Abbreviation: Int. J. Biochem. Cell Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-07-26 Completed Date: 2010-11-01 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 9508482 Medline TA: Int J Biochem Cell Biol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 1430-45 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medical Neurobiology, The Institute of Medical Research Israel-Canada and the Kühne Minerva Center, for Studies of Visual Transduction, Faculty of Medicine, The Hebrew University, Jerusalem 91120, Israel. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Cell Death / genetics, physiology* Cell Differentiation / genetics, physiology Cell Proliferation Humans Models, Biological Synaptic Vesicles / metabolism Transient Receptor Potential Channels / genetics, metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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EY 03529/EY/NEI NIH HHS; R01 EY003529-30/EY/NEI NIH HHS; R01 EY003529-31/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Transient Receptor Potential Channels; 7440-70-2/Calcium |
| Comments/Corrections | |
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