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Cellular Electrophysiological Abnormalities in Dyssynchronous Hearts and During CRT.
MedLine Citation:
PMID:  22147586     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
To date, cardiac resynchronization therapy remains the only treatment that enhances systolic function while improving long-term outcome and survival. Dyssynchronous heart failure is characterized by profound global as well as regional cellular and molecular changes, many of which are not observed in synchronous heart failure. The beneficial effects of CRT on myofilament function, G protein-coupled receptor signaling, and adrenergic response are important components for restoring cardiac reserve and reducing arrhythmia, both major limitations in heart failure. Here, we review the molecular alterations associated with dyssynchronous heart failure and their reversibility induced by cardiac resynchronization therapy.
Authors:
Marc Vanderheyden; Martin Penicka; Jozef Bartunek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-7
Journal Detail:
Title:  Journal of cardiovascular translational research     Volume:  -     ISSN:  1937-5395     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101468585     Medline TA:  J Cardiovasc Transl Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Cardiovascular Center, Onze Lieve Vrouwziekenhuis, Moorselbaan 164, 9400, Aalst, Belgium, marc.vanderheyden@skynet.be.
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