Document Detail


Cellular Ca2+ homeostasis and Ca2+-mediated cell processes as critical targets for toxicant action: conceptual and methodological pitfalls.
MedLine Citation:
PMID:  3041648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Because of the central role of the calcium messenger system in diverse functions of tissues, organs, and cells, Ca2+ homeostasis and function may prove to be critical cellular and molecular targets for a diverse range of toxicants. Experimental proof of these targets as a specific site of toxicant action is challenging and technically difficult as a result of the complexity of Ca2+ homeostatic and Ca2+-mediated processes. However, as the investigation of normal physiological control of Ca2+ and function will continue to be an active and productive area of basic research for several years to come, it is anticipated that these insights will be increasingly applied to the understanding of the mechanisms of action of toxic agents.
Authors:
J G Pounds; J F Rosen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  94     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-09-02     Completed Date:  1988-09-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  331-41     Citation Subset:  IM    
Affiliation:
Department of Applied Science, Brookhaven National Laboratory, Upton, New York 11973.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport
Calcium / metabolism*
Homeostasis / drug effects*
Humans
Toxicology*
Grant Support
ID/Acronym/Agency:
ES01060/ES/NIEHS NIH HHS; ES04039/ES/NIEHS NIH HHS; ES04040/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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