| The Cellular Anti-viral Restriction Factor Tetherin Does Not Inhibit Poxviral Replication. | |
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MedLine Citation:
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PMID: 22090135 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Interferon-stimulated genes fulfill innate antiviral effector functions. Among them, tetherin (THN) blocks the release of many enveloped viruses from infected cells. Vaccinia (VACV) encodes immune modulators interfering with antiviral host responses. Therefore, it was tempting to study a potential VACV-THN interaction. Remarkably, THN expression did not inhibit VACV release and replication. VACV infection did not diminish THN-surface levels or impaired its function on retroviral release. This suggests that THN is unable to restrict VACV replication. |
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Authors:
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Katja Sliva; Theresa Resch; Benjamin Kraus; Christine Goffinet; Oliver T Keppler; Barbara S Schnierle |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
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Title: Journal of virology Volume: - ISSN: 1098-5514 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Paul-Ehrlich-Institut, Paul-Ehrlich-Strasse 51-59, 63225 Langen. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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