Document Detail


Cells of origin and tumor-initiating cells for nonmelanoma skin cancers.
MedLine Citation:
PMID:  22579650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The epidermis of the skin is a multilayered stratified epithelium whose primary function is to provide a barrier against our external environment. As a result, cells in the epidermis are subject to constant assault from environmental pathogens, many of which can cause deleterious mutations. However, most of these mutations do not lead to skin cancer. One explanation is that most genetic hits are sustained by mature or transit cells with limited proliferative capacity and only stem cells that acquire genetic alterations have the potential to propagate a frank tumor. In this mini-review we will discuss recent studies that provide some of the first genetic evidence to support a stem cell origin for a number of skin cancer types.
Authors:
Khanh Thieu; Marlon E Ruiz; David M Owens
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-05-11
Journal Detail:
Title:  Cancer letters     Volume:  338     ISSN:  1872-7980     ISO Abbreviation:  Cancer Lett.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-26     Completed Date:  2013-11-06     Revised Date:  2014-10-16    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  82-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Cell Transformation, Neoplastic / genetics
Clonal Evolution*
Epidermis / metabolism,  pathology
Humans
Mutation
Neoplastic Stem Cells / metabolism,  pathology*
Proto-Oncogene Proteins p21(ras) / genetics
Skin Neoplasms / genetics,  pathology*
Stem Cell Niche*
Tumor Suppressor Protein p53 / genetics
Grant Support
ID/Acronym/Agency:
P30 AR044535/AR/NIAMS NIH HHS; R01 CA114014/CA/NCI NIH HHS; R01CA114014/CA/NCI NIH HHS; R21 ES020060/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53; EC 3.6.5.2/Proto-Oncogene Proteins p21(ras)
Comments/Corrections

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