Document Detail


Cells in cryptophycin-induced cell-cycle arrest are susceptible to apoptosis.
MedLine Citation:
PMID:  10766419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Exposure of murine leukemia L1210 cells to the antitumor antibiotic cryptophycin 52 (C52) led to cell-cycle arrest at the prometaphase/metaphase interface within 18 h, but apoptotic nuclei did not appear until 36 h later. To determine whether accumulation of cells in early metaphase might have delayed the apoptotic process, cells were treated with C52 for 18 h and a photodynamic process was used to initiate the release of mitochondrial cytochrome c. Apoptosis was observed within 60 min, indicating that the slow apoptotic response was not caused by an impaired ability of genomic DNA to undergo endonucleosomal cleavage during cell-cycle arrest induced by cryptophycin 52.
Authors:
D Kessel; Y Luo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer letters     Volume:  151     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-05-01     Completed Date:  2000-05-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  25-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, Wayne State University School of Medicine, Detroit, MI 48201, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents / toxicity*
Apoptosis / drug effects,  physiology*
Caspase 3
Caspases / metabolism
Cell Cycle / drug effects*
Cell Nucleus / drug effects,  pathology
Cell Survival / drug effects
Chromatin / drug effects,  pathology
Depsipeptides
Enzyme Activation
Kinetics
Leukemia L1210 / pathology*
Mice
Mitochondria / drug effects,  pathology
Peptide Hydrolases / metabolism
Peptides, Cyclic / toxicity*
Tumor Cells, Cultured
Grant Support
ID/Acronym/Agency:
CA 23378/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Chromatin; 0/Depsipeptides; 0/Peptides, Cyclic; 124689-65-2/cryptophycin; EC 3.4.-/Peptide Hydrolases; EC 3.4.22.-/Casp3 protein, mouse; EC 3.4.22.-/Caspase 3; EC 3.4.22.-/Caspases; EC 3.4.99.-/DEVDase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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