Document Detail


Cells of extraembryonic mesodermal origin confer human dystrophin in the mdx model of Duchenne muscular dystrophy.
MedLine Citation:
PMID:  20162617     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Duchenne muscular dystrophy is an X-linked recessive genetic disease characterized by severe skeletal muscular degeneration. The placenta is considered to be a promising candidate cell source for cellular therapeutics because it contains a large number of cells and heterogenous cell populations with myogenic potentials. We analyzed the myogenic potential of cells obtained from six parts of the placenta, that is, umbilical cord, amniotic epithelium, amniotic mesoderm, chorionic plate, villous chorion, and decidua basalis. In vitro cells derived from amniotic mesoderm, chorionic plate, and villous chorion efficiently transdifferentiate into myotubes. In addition, in vivo implantation of placenta-derived cells into dystrophic muscles of immunodeficient mdx mice restored sarcolemmal expression of human dystrophin. Differential contribution to myogenesis in this study may be attributed to placental portion-dependent default cell state. Molecular taxonomic characterization of placenta-derived maternal and fetal cells in vitro will help determine the feasibility of cell-based therapy.
Authors:
Yayoi Kawamichi; Chang-Hao Cui; Masashi Toyoda; Hatsune Makino; Akane Horie; Yoriko Takahashi; Kenji Matsumoto; Hirohisa Saito; Hiroaki Ohta; Kayoko Saito; Akihiro Umezawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  223     ISSN:  1097-4652     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-04-07     Completed Date:  2010-04-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM    
Copyright Information:
(c) 2010 Wiley-Liss, Inc.
Affiliation:
Department of Reproductive Biology, National Institute for Child Health and Development, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / metabolism
Cell Membrane / metabolism
Cell Shape
Cell Transplantation
Disease Models, Animal
Dystrophin / metabolism*
Extraembryonic Membranes / cytology*,  transplantation*
Female
Humans
Mesoderm / cytology*,  transplantation*
Mice
Mice, Inbred mdx
Mice, SCID
Muscle Development
Muscle Fibers, Skeletal / metabolism,  pathology
Muscular Dystrophy, Duchenne / metabolism,  pathology,  therapy*
Oligonucleotide Array Sequence Analysis
Placenta / cytology
Pregnancy
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Dystrophin

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