Document Detail

Cells as factories for humanized encapsulation.
MedLine Citation:
PMID:  21486057     Owner:  NLM     Status:  MEDLINE    
Biocompatibility is of paramount importance for drug delivery, tumor labeling, and in vivo application of nanoscale bioprobes. Until now, biocompatible surface processing has typically relied on PEGylation and other surface coatings, which, however, cannot minimize clearance by macrophages or the renal system but may also increase the risk of chemical side effects. Cell membranes provide a generic and far more natural approach to the challenges of encapsulation and delivery in vivo. Here we harness for the first time living cells as "factories" to manufacture cell membrane capsules for encapsulation and delivery of drugs, nanoparticles, and other biolabels. Furthermore, we demonstrate that the built-in protein channels of the new capsules can be utilized for controlled release of encapsulated reagents.
Zhengwei Mao; Regis Cartier; Anja Hohl; Maura Farinacci; Anca Dorhoi; Tich-Lam Nguyen; Paul Mulvaney; John Ralston; Stefan H E Kaufmann; Helmuth Möhwald; Dayang Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-04-12
Journal Detail:
Title:  Nano letters     Volume:  11     ISSN:  1530-6992     ISO Abbreviation:  Nano Lett.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-05-11     Completed Date:  2011-10-14     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  101088070     Medline TA:  Nano Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2152-6     Citation Subset:  IM    
Max Planck Institute of Colloids and Interfaces, D-14424, Potsdam, Germany.
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MeSH Terms
Biocompatible Materials / chemistry*
Cell Line
Cell Membrane / metabolism
Cytoplasm / metabolism
Drug Delivery Systems
Macrophages / metabolism
Microscopy, Fluorescence / methods
Nanoparticles / chemistry
Nanotechnology / methods*
Polyethylene Glycols / chemistry
Surface Properties
Reg. No./Substance:
0/Biocompatible Materials; 0/Capsules; 0/Polyethylene Glycols
Comment In:
Nanomedicine (Lond). 2011 Aug;6(6):953-5   [PMID:  21955075 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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