| Cells as factories for humanized encapsulation. | |
| | |
MedLine Citation:
|
PMID: 21486057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Biocompatibility is of paramount importance for drug delivery, tumor labeling, and in vivo application of nanoscale bioprobes. Until now, biocompatible surface processing has typically relied on PEGylation and other surface coatings, which, however, cannot minimize clearance by macrophages or the renal system but may also increase the risk of chemical side effects. Cell membranes provide a generic and far more natural approach to the challenges of encapsulation and delivery in vivo. Here we harness for the first time living cells as "factories" to manufacture cell membrane capsules for encapsulation and delivery of drugs, nanoparticles, and other biolabels. Furthermore, we demonstrate that the built-in protein channels of the new capsules can be utilized for controlled release of encapsulated reagents. |
| | |
Authors:
|
Zhengwei Mao; Regis Cartier; Anja Hohl; Maura Farinacci; Anca Dorhoi; Tich-Lam Nguyen; Paul Mulvaney; John Ralston; Stefan H E Kaufmann; Helmuth Möhwald; Dayang Wang |
Related Documents
:
|
19527377 - Rna interference targeting of sphingomyelin phosphodiesterase 1 protects human granulos... 14982037 - Inhibitory effect of heat shock protein 70 on apoptosis induced by photodynamic therapy... 17321467 - Nonylphenol induces apoptosis of jurkat cells by a caspase-8 dependent mechanism. 21272007 - Singlet oxygen sensor green(®) : photochemical behavior in solution and in a mammalian... 11121437 - Expression of cd34 and myf5 defines the majority of quiescent adult skeletal muscle sat... 8620577 - Metabolism of benz[alpha]anthracene by human bone marrow in vitro. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2011-04-12 |
Journal Detail:
|
Title: Nano letters Volume: 11 ISSN: 1530-6992 ISO Abbreviation: Nano Lett. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-11 Completed Date: 2011-10-14 Revised Date: 2011-11-02 |
Medline Journal Info:
|
Nlm Unique ID: 101088070 Medline TA: Nano Lett Country: United States |
Other Details:
|
Languages: eng Pagination: 2152-6 Citation Subset: IM |
Affiliation:
|
Max Planck Institute of Colloids and Interfaces, D-14424, Potsdam, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Biocompatible Materials
/
chemistry* Capsules Cell Line Cell Membrane / metabolism Cytoplasm / metabolism Drug Delivery Systems Humans Macrophages / metabolism Microscopy, Fluorescence / methods Nanoparticles / chemistry Nanotechnology / methods* Polyethylene Glycols / chemistry Surface Properties |
| Chemical | |
Reg. No./Substance:
|
0/Biocompatible Materials; 0/Capsules; 0/Polyethylene Glycols |
| Comments/Corrections | |
Comment In:
|
Nanomedicine (Lond). 2011 Aug;6(6):953-5
[PMID:
21955075
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-Pressure Study of Lithium Azide from Density-Functional Calculations.
Next Document: Carba-sugars activate the glmS-riboswitch of Staphylococcus aureus.