| Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage. | |
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MedLine Citation:
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PMID: 19064919 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Auditory hair cell defect is a major cause of hearing impairment, often leading to spiral ganglia neuron (SGN) degeneration. The cell loss that follows is irreversible in mammals, because inner ear hair cells (HCs) have a limited capacity to regenerate. Here, we report that in the adult brain of both rodents and humans, the ependymal layer of the lateral ventricle contains cells with proliferative potential, which share morphological and functional characteristics with HCs. In addition, putative neural stem cells (NSCs) from the subventricular zone of the lateral ventricle can differentiate into functional SGNs. Also important, the NSCs can incorporate into the sensory epithelia, demonstrating their therapeutic potential. We assert that NSCs and edendymal cells can undergo an epigenetic functional switch to assume functional characteristics of HCs and SGNs. This study suggests that the functional plasticity of renewable cells and conditions that promote functional reprogramming can be used for cell therapy in the auditory setting. |
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Authors:
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Dongguang Wei; Snezana Levic; Liping Nie; Wei-qiang Gao; Christine Petit; Edward G Jones; Ebenezer N Yamoah |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-12-08 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 105 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-31 Completed Date: 2009-01-27 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 21000-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Pain Medicine, Center for Neuroscience, Program in Communication and Sensory Science, University of California, 1544 Newton Court, Davis, CA 95618, USA. donwei@ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology* Cells, Cultured Ependyma / cytology*, metabolism Hair Cells, Auditory / cytology*, metabolism Humans Mice Mice, Transgenic Regeneration / physiology* Spiral Ganglion / cytology* Stem Cells / cytology*, metabolism |
| Comments/Corrections | |
Comment In:
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Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):8-9
[PMID:
19118205
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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