Document Detail


Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage.
MedLine Citation:
PMID:  19064919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Auditory hair cell defect is a major cause of hearing impairment, often leading to spiral ganglia neuron (SGN) degeneration. The cell loss that follows is irreversible in mammals, because inner ear hair cells (HCs) have a limited capacity to regenerate. Here, we report that in the adult brain of both rodents and humans, the ependymal layer of the lateral ventricle contains cells with proliferative potential, which share morphological and functional characteristics with HCs. In addition, putative neural stem cells (NSCs) from the subventricular zone of the lateral ventricle can differentiate into functional SGNs. Also important, the NSCs can incorporate into the sensory epithelia, demonstrating their therapeutic potential. We assert that NSCs and edendymal cells can undergo an epigenetic functional switch to assume functional characteristics of HCs and SGNs. This study suggests that the functional plasticity of renewable cells and conditions that promote functional reprogramming can be used for cell therapy in the auditory setting.
Authors:
Dongguang Wei; Snezana Levic; Liping Nie; Wei-qiang Gao; Christine Petit; Edward G Jones; Ebenezer N Yamoah
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-12-08
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  105     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-31     Completed Date:  2009-01-27     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  21000-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation / physiology*
Cells, Cultured
Ependyma / cytology*,  metabolism
Hair Cells, Auditory / cytology*,  metabolism
Humans
Mice
Mice, Transgenic
Regeneration / physiology*
Spiral Ganglion / cytology*
Stem Cells / cytology*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 DC010917/DC/NIDCD NIH HHS
Comments/Corrections
Comment In:
Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):8-9   [PMID:  19118205 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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