| Cell(MC3T3-E1)-Printed Poly(ϵ-caprolactone)/Alginate Hybrid Scaffolds for Tissue Regeneration. | |
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MedLine Citation:
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PMID: 23059986 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A new cell-printed scaffold consisting of poly(ϵ-caprolactone) (PCL) and cell-embedded alginate struts is designed. The PCL and alginate struts are stacked in an interdigitated pattern in successive layers to acquire a three-dimensional (3D) shape. The hybrid scaffold exhibits a two-phase structure consisting of cell (MC3T3-E1)-laden alginate struts able to support biological activity and PCL struts able to provide controllable mechanical support of the cell-laden alginate struts. The hybrid scaffolds exhibit an impressive increase in tensile modulus and maximum strength compared to pure alginate scaffolds. Laden cells are homogeneously distributed throughout the alginate struts and the entire scaffold, resulting in cell viability of approximately 84%. |
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Authors:
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Hyeongjin Lee; Seunghyun Ahn; Lawrence J Bonassar; Geunhyung Kim |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
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Title: Macromolecular rapid communications Volume: - ISSN: 1521-3927 ISO Abbreviation: Macromol Rapid Commun Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9888239 Medline TA: Macromol Rapid Commun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Department of Mechanical Engineering, Chosun University, GwangJu, South Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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