Document Detail

Cell volume regulation and swelling-activated chloride channels.
MedLine Citation:
PMID:  14729152     Owner:  NLM     Status:  MEDLINE    
Maintenance of a constant volume is essential for normal cell function. Following cell swelling, as a consequence of reduction of extracellular osmolarity or increase of intracellular content of osmolytes, animal cells are able to restore their original volume by activation of potassium and chloride conductances. The loss of these ions, followed passively by water, is responsible for the homeostatic response called regulatory volume decrease (RVD). Activation of a chloride conductance upon cell swelling is a key step in RVD. Several proteins have been proposed as candidates for this chloride conductance. The status of the field is reviewed, with particular emphasis on ClC-3, a member of the ClC family which has been recently proposed as the chloride channel involved in cell volume regulation.
Alessandro Sardini; Joanna S Amey; Karsten Henrich Weylandt; Muriel Nobles; Miguel Angel Valverde; Christopher F Higgins
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1618     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2004-01-19     Completed Date:  2004-03-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  153-62     Citation Subset:  IM    
MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital Campus, Du Cane Road, London W12 0NN, UK.
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MeSH Terms
Cell Line
Cell Size / physiology*
Chloride Channels / genetics,  metabolism,  physiology*
Chlorides / chemistry,  metabolism
Electric Conductivity
Potassium / chemistry,  metabolism
Potassium Channels / metabolism
Water / metabolism
Water-Electrolyte Balance
Reg. No./Substance:
0/Chloride Channels; 0/Chlorides; 0/ClC-3 channel; 0/Potassium Channels; 7440-09-7/Potassium; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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