Document Detail

Cell volume regulation: physiology and pathophysiology.
MedLine Citation:
PMID:  18945273     Owner:  NLM     Status:  MEDLINE    
Cell volume perturbation initiates a wide array of intracellular signalling cascades, leading to protective and adaptive events and, in most cases, activation of volume-regulatory osmolyte transport, water loss, and hence restoration of cell volume and cellular function. Cell volume is challenged not only under physiological conditions, e.g. following accumulation of nutrients, during epithelial absorption/secretion processes, following hormonal/autocrine stimulation, and during induction of apoptosis, but also under pathophysiological conditions, e.g. hypoxia, ischaemia and hyponatremia/hypernatremia. On the other hand, it has recently become clear that an increase or reduction in cell volume can also serve as a specific signal in the regulation of physiological processes such as transepithelial transport, cell migration, proliferation and death. Although the mechanisms by which cell volume perturbations are sensed are still far from clear, significant progress has been made with respect to the nature of the sensors, transducers and effectors that convert a change in cell volume into a physiological response. In the present review, we summarize recent major developments in the field, and emphasize the relationship between cell volume regulation and organism physiology/pathophysiology.
I H Lambert; E K Hoffmann; S F Pedersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-10-06
Journal Detail:
Title:  Acta physiologica (Oxford, England)     Volume:  194     ISSN:  1748-1716     ISO Abbreviation:  Acta Physiol (Oxf)     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-08-05     Revised Date:  2011-05-12    
Medline Journal Info:
Nlm Unique ID:  101262545     Medline TA:  Acta Physiol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  255-82     Citation Subset:  IM    
Department of Biology, University of Copenhagen, Copenhagen, Denmark.
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MeSH Terms
Actins / physiology
Apoptosis / physiology
Biological Transport / physiology
Carrier Proteins / physiology*
Cell Movement / physiology
Cell Size*
Cytoskeleton / physiology*
Growth Substances / physiology
Integrins / physiology
Ion Channels / physiology
Protein Kinases / physiology*
Taurine / physiology*
Reg. No./Substance:
0/Actins; 0/Carrier Proteins; 0/Growth Substances; 0/Integrins; 0/Ion Channels; 107-35-7/Taurine; EC 2.7.-/Protein Kinases

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