Document Detail

Cell volume regulation: osmolytes, osmolyte transport, and signal transduction.
MedLine Citation:
PMID:  12687402     Owner:  NLM     Status:  MEDLINE    
In recent years, it has become evident that the volume of a given cell is an important factor not only in defining its intracellular osmolality and its shape, but also in defining other cellular functions, such as transepithelial transport, cell migration, cell growth, cell death, and the regulation of intracellular metabolism. In addition, besides inorganic osmolytes, the existence of organic osmolytes in cells has been discovered. Osmolyte transport systems-channels and carriers alike-have been identified and characterized at a molecular level and also, to a certain extent, the intracellular signals regulating osmolyte movements across the plasma membrane. The current review reflects these developments and focuses on the contributions of inorganic and organic osmolytes and their transport systems in regulatory volume increase (RVI) and regulatory volume decrease (RVD) in a variety of cells. Furthermore, the current knowledge on signal transduction in volume regulation is compiled, revealing an astonishing diversity in transport systems, as well as of regulatory signals. The information available indicates the existence of intricate spatial and temporal networks that control cell volume and that we are just beginning to be able to investigate and to understand.
F Wehner; H Olsen; H Tinel; E Kinne-Saffran; R K H Kinne
Publication Detail:
Type:  Journal Article; Review     Date:  2003-04-04
Journal Detail:
Title:  Reviews of physiology, biochemistry and pharmacology     Volume:  148     ISSN:  0303-4240     ISO Abbreviation:  Rev. Physiol. Biochem. Pharmacol.     Publication Date:  2003  
Date Detail:
Created Date:  2003-09-23     Completed Date:  2004-02-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0434624     Medline TA:  Rev Physiol Biochem Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-80     Citation Subset:  IM    
Max-Planck-Institut für molekulare Physiologie, Otto-Hahn-Str. 11, 44227, Dortmund, Germany.
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MeSH Terms
Biological Transport
Cell Size*
Electrolytes / chemistry*
Signal Transduction*
Reg. No./Substance:

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