| Cell volume homeostasis: ionic and nonionic mechanisms. The sodium pump in the emergence of animal cells. | |
MedLine Citation:
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PMID: 11952230 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plant cells and bacterial cells are surrounded by a massive polysaccharide wall, which constrains their high internal osmotic pressure (tens of atmospheres). Animal cells, in contrast, are in osmotic equilibrium with their environment, have no restraining surround, and can take on a variety of shapes and can change these from moment to moment. This osmotic balance is achieved, in the first place, by the action of the energy-consuming sodium pump, one of the P-type ATPase transport protein family, members of which are found also in bacteria. The pump's action brings about a transmembranal electrochemical gradient of sodium ions, harnessed in a range of transport systems which couple the dissipation of this gradient to establishing a gradient of the coupled substrate. These transport systems include many which are responsible for short-term regulation of the cell's volume in response to acute changes of their osmotic balance. Thus, the primary role of the sodium pump as a regulator of cell volume has been built upon to provide the basis for an enormous variety of physiological functions. |
Authors:
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Wilfred D Stein |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: International review of cytology Volume: 215 ISSN: 0074-7696 ISO Abbreviation: Int. Rev. Cytol. Publication Date: 2002 |
Date Detail:
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Created Date: 2002-04-15 Completed Date: 2002-10-10 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 2985180R Medline TA: Int Rev Cytol Country: United States |
Other Details:
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Languages: eng Pagination: 231-58 Citation Subset: IM |
Affiliation:
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Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Membrane / metabolism*, ultrastructure Cell Membrane Permeability / physiology Cell Size / physiology* Eukaryotic Cells / metabolism*, ultrastructure Evolution, Molecular Homeostasis / physiology* Humans Ions / metabolism* Sodium-Potassium-Exchanging ATPase / metabolism* Water-Electrolyte Balance / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Ions; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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