Document Detail


Cell volume homeostasis: ionic and nonionic mechanisms. The sodium pump in the emergence of animal cells.
MedLine Citation:
PMID:  11952230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Plant cells and bacterial cells are surrounded by a massive polysaccharide wall, which constrains their high internal osmotic pressure (tens of atmospheres). Animal cells, in contrast, are in osmotic equilibrium with their environment, have no restraining surround, and can take on a variety of shapes and can change these from moment to moment. This osmotic balance is achieved, in the first place, by the action of the energy-consuming sodium pump, one of the P-type ATPase transport protein family, members of which are found also in bacteria. The pump's action brings about a transmembranal electrochemical gradient of sodium ions, harnessed in a range of transport systems which couple the dissipation of this gradient to establishing a gradient of the coupled substrate. These transport systems include many which are responsible for short-term regulation of the cell's volume in response to acute changes of their osmotic balance. Thus, the primary role of the sodium pump as a regulator of cell volume has been built upon to provide the basis for an enormous variety of physiological functions.
Authors:
Wilfred D Stein
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  International review of cytology     Volume:  215     ISSN:  0074-7696     ISO Abbreviation:  Int. Rev. Cytol.     Publication Date:  2002  
Date Detail:
Created Date:  2002-04-15     Completed Date:  2002-10-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985180R     Medline TA:  Int Rev Cytol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  231-58     Citation Subset:  IM    
Affiliation:
Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / metabolism*,  ultrastructure
Cell Membrane Permeability / physiology
Cell Size / physiology*
Eukaryotic Cells / metabolism*,  ultrastructure
Evolution, Molecular
Homeostasis / physiology*
Humans
Ions / metabolism*
Sodium-Potassium-Exchanging ATPase / metabolism*
Water-Electrolyte Balance / physiology*
Chemical
Reg. No./Substance:
0/Ions; EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

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