| Cell type-specific resistance of trigeminal ganglion neurons towards apoptotic stimuli. | |
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MedLine Citation:
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PMID: 16326038 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trigeminal ganglion (TG) neurons are important target cells for many alphaherpesviruses and constitute a major site of virus latency and reactivation. Earlier we showed that porcine TG neurons are remarkably more resistant towards (apoptotic) cell death resulting from infection by the swine alphaherpesvirus pseudorabies virus (PRV) compared to a broad range of other primary porcine cell types and that this resistance does not depend on the strongly anti-apoptotic US3 viral protein kinase (Geenen, K., Favoreel, H.W., Nauwynck, H.J., 2005a. Higher resistance of porcine trigeminal ganglion neurons towards pseudorabies virus-induced cell death compared with other porcine cell types in vitro. J. Gen. Virol. 86, 1251-1260). Although other viral anti-apoptotic proteins may be involved in survival of TG neurons during PRV infection, an additional factor may be that TG neurons possess a cell type-dependent capacity to withstand apoptosis compared to other cell types. To investigate this, we treated uninfected porcine TG cultures, swine kidney cells, and porcine superior cervical ganglion (SCG) neurons with several apoptosis-inducing reagents (staurosporine, camptothecin and genistein). None of these reagents were able to trigger substantial apoptotic cell death in TG neurons, whereas non-neuronal TG cells, swine kidney cells, and SCG neurons showed a clear dose-dependent increase in apoptosis using either of these reagents. In conclusion, sensory TG neurons may contain a cell type-specific capacity to withstand different apoptotic assaults, including infection with an alphaherpesvirus. |
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Authors:
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Kristin Geenen; Herman W Favoreel; Hans J Nauwynck |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-12-02 |
Journal Detail:
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Title: Veterinary microbiology Volume: 113 ISSN: 0378-1135 ISO Abbreviation: Vet. Microbiol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-06 Completed Date: 2006-07-18 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7705469 Medline TA: Vet Microbiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 223-9 Citation Subset: IM |
Affiliation:
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Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* / drug effects, physiology Camptothecin / pharmacology Cells, Cultured Dose-Response Relationship, Drug Enzyme Inhibitors / pharmacology* Genistein / pharmacology Herpesvirus 1, Suid / enzymology, pathogenicity* Neurons / cytology, drug effects, virology* Protein Kinases / metabolism, physiology Pseudorabies / virology* Staurosporine / pharmacology Swine Trigeminal Ganglion / cytology, drug effects, virology* Virus Latency |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 446-72-0/Genistein; 62996-74-1/Staurosporine; 7689-03-4/Camptothecin; EC 2.7.-/Protein Kinases |
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