| Cell type-specific regulation of IL-10 expression in inflammation and disease. | |
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MedLine Citation:
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PMID: 20087682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-10 plays an essential part in controlling inflammation and instructing adaptive immune responses. Consequently, dysregulation of IL-10 is linked with susceptibility to numerous infectious and autoimmune diseases in mouse models and in humans. It has become increasingly clear that appropriate temporal/spatial expression of IL-10 may be the key to how IL-10 contributes to the delicate balance between inflammation and immunoregulation. The mechanisms that govern the cell type- and receptor-specific induction of IL-10, however, remain unclear. This is due largely to the wide distribution of cellular sources that express IL-10 under diverse stimulation conditions and in a variety of tissue compartments. Further complicating the issue is the fact that human IL-10 expression patterns appear to be under genetic influence resulting in differential expression and disease susceptibility. In this review, we discuss the cellular sources of IL-10, their link to disease phenotypes and the molecular mechanisms implicated in IL-10 regulation. |
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Authors:
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Christian M Hedrich; Jay H Bream |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Immunologic research Volume: 47 ISSN: 1559-0755 ISO Abbreviation: Immunol. Res. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-23 Completed Date: 2010-10-21 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8611087 Medline TA: Immunol Res Country: United States |
Other Details:
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Languages: eng Pagination: 185-206 Citation Subset: IM |
Affiliation:
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W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Room E5624, Baltimore, MD 21205-1901, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Autoimmune Diseases / immunology* Dendritic Cells / immunology, metabolism Gene Expression Regulation / immunology* Humans Immunity, Cellular* Infection / immunology* Inflammation / immunology* Interleukin-10 / genetics, metabolism* Macrophages / immunology, metabolism Mice T-Lymphocytes / immunology, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 AI070594-03/AI/NIAID NIH HHS; R01 AI070594-05/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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130068-27-8/Interleukin-10 |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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