Document Detail


Cell type-specific expression of adenomatous polyposis coli in lung development, injury, and repair.
MedLine Citation:
PMID:  20658693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adenomatous polyposis coli (Apc) is critical for Wnt signaling and cell migration. The current study examined Apc expression during lung development, injury, and repair. Apc was first detectable in smooth muscle layers in early lung morphogenesis, and was highly expressed in ciliated and neuroendocrine cells in the advanced stages. No Apc immunoreactivity was detected in Clara or basal cells, which function as stem/progenitor cell in adult lung. In ciliated cells, Apc is associated mainly with apical cytoplasmic domain. In response to naphthalene-induced injury, Apc(positive) cells underwent squamous metaplasia, accompanied by changes in Apc subcellular distribution. In conclusion, both spatial and temporal expression of Apc is dynamically regulated during lung development and injury repair. Differential expression of Apc in progenitor vs. nonprogenitor cells suggests a functional role in cell-type specification. Subcellular localization changes of Apc in response to naphthalene injury suggest a role in cell shape and cell migration.
Authors:
Aimin Li; Yiming Xing; Belinda Chan; Nora Heisterkamp; John Groffen; Zea Borok; Parviz Minoo; Changgong Li
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental dynamics : an official publication of the American Association of Anatomists     Volume:  239     ISSN:  1097-0177     ISO Abbreviation:  Dev. Dyn.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-11-23     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  9201927     Medline TA:  Dev Dyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2288-97     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adenomatous Polyposis Coli Protein / analysis*,  genetics
Gene Expression Regulation / physiology*
Lung / chemistry*,  growth & development,  physiology
Lung Injury / chemically induced
Naphthalenes / pharmacology
Regeneration / genetics
Stem Cells / metabolism
Tissue Distribution
Wound Healing / genetics
Grant Support
ID/Acronym/Agency:
HL060231/HL/NHLBI NIH HHS; HL071945/HL/NHLBI NIH HHS; HL075334/HL/NHLBI NIH HHS; R01 HL075334-05/HL/NHLBI NIH HHS; R01 HL089445/HL/NHLBI NIH HHS; R37 HL062569/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adenomatous Polyposis Coli Protein; 0/Naphthalenes; 2166IN72UN/naphthalene
Comments/Corrections

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