Document Detail

Cell type accuracy of bronchial biopsy specimens in primary lung cancer.
MedLine Citation:
PMID:  8625667     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To evaluate the diagnostic accuracy of bronchial biopsy (BB) specimens in establishing the specific cell type in primary lung cancer (LC), and to study the influence of several factors on this accuracy. SETTING: Tertiary health-care center. PATIENTS: One hundred forty-six patients with LC diagnosed by BB specimens who underwent thoracotomy (T). MEASUREMENTS: We have studied the specific LC cell type observed in the BB specimen and compared it with the T specimen (reference diagnosis). Age, location and type of bronchial lesion, number and size of the biopsy fragments, tumoral size, sample necrosis, degree of cell differentiation, tumoral stage, pathologist's experience, and the presence of other diagnostic tests with the same cell type were analyzed to assess their influence on the concordance between the two diagnoses. RESULTS: The overall concordance between BB and T histologic diagnosis was 0.70 (kappa coefficient [K]). Of the different histologic types, the worst result was obtained in large cell carcinoma (LLC) (K, 0.49). Squamous carcinoma and adenocarcinoma gave similar results (0.74 and 0.77, respectively), while small cell lung cancer (SCLC) only reached a value of 0.60. The degree of cell differentiation, the absence of necrosis, and presence of other preoperative diagnoses were the variables that most influenced the histologic accuracy of BB specimens. Therefore, the probability of BB accuracy was 2.7, 7.7, and 25 times higher in well-differentiated, than in poorly differentiated, moderately differentiated, or undifferentiated carcinomas; 5.2 times higher when there was no necrosis in the sample; and 7.43 higher when there was another preoperative diagnosis. CONCLUSIONS: The histologic results of BB must be examined carefully, especially in cellular subtypes like LLC. The absence of differentiation and presence of necrosis in BB samples were the factors that require the greatest caution in ascertaining the cell type. When they are involved and also in all cases in which identifying the specific cell type has important implications, we prefer to classify the patients as having SCLC or non-small cell lung cancer, and then reclassify them later after using a second diagnostic technique.
J J Cataluña; M Perpiñá; J V Greses; V Calvo; J D Padilla; F París
Related Documents :
6988097 - Cell kinetics of human squamous cell carcinomas in the oral cavity.
12398537 - Spirostanol pentaglycosides from the underground parts of polianthestuberosa.
15094227 - Cortistatin production by hepg2 human hepatocellular carcinoma cell line and distributi...
8149487 - Co-expression of human cyp1a1 and a human analog of cytochrome p450-ef in response to 2...
24390567 - Transduction of extracellular cues into cell polarity: the role of the transmembrane pr...
17544257 - Multiple proteins mediate iqgap1-stimulated cell migration.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  109     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-06-27     Completed Date:  1996-06-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1199-203     Citation Subset:  AIM; IM    
Hospital Universitario La Fe, Servicio de Neumología y Cirugía Torácica, Valencia, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adenocarcinoma / diagnosis,  pathology
Bronchi / pathology*
Carcinoma, Non-Small-Cell Lung / diagnosis,  pathology
Carcinoma, Small Cell / diagnosis,  pathology
Carcinoma, Squamous Cell / diagnosis,  pathology
Lung Neoplasms / diagnosis*,  pathology,  surgery
Middle Aged
Comment In:
Chest. 1996 May;109(5):1138-9   [PMID:  8625654 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A randomized, double-blind, placebo-controlled study of lorazepam as premedication for bronchoscopy.
Next Document:  Comparison of quantitative cultures to semiquantitative loop cultures of bronchoscopic protected spe...